Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | DHODH | Q02127 | 3/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12136237 | 0.76 | LMNA (0.51) | SMN1; SMN2LMNAHPGDDHODHKDM4E | |
| SCHEMBL5857457 | 0.75 | ADORA1 (0.44) | SMN1; SMN2LMNAHPGDDHODHKDM4E | |
| SCHEMBL4848138 | 0.74 | IKBKB (0.61) | SMN1; SMN2LMNAHPGDDHODHCYP19A1 | |
| SCHEMBL14034296 | 0.73 | ALDH1A1 (0.54) | SMN1; SMN2LMNAHPGDDHODHCYP19A1 | |
| SCHEMBL4849623 | 0.73 | DHODH (0.48) | SMN1; SMN2LMNAHPGDDHODHCYP19A1 | |
| SCHEMBL4250010 | 0.73 | ACHE (0.67) | SMN1; SMN2LMNAHPGDDHODHCYP19A1 | |
| SCHEMBL4251041 | 0.72 | KDM4E (0.69) | SMN1; SMN2LMNADHODHKDM4EALDH1A1 | |
| SCHEMBL4848344 | 0.70 | CYP2C9 (0.50) | LMNAHPGDKDM4EMEN1KMT2A | |
| SCHEMBL18455618 | 0.69 | KMT2A (0.52) | LMNAHPGDDHODHKDM4EMEN1 | |
| SCHEMBL18455609 | 0.69 | KDM4E (0.68) | LMNAHPGDDHODHKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060142324-A1 | Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands | NEUROGEN CORPORATION | 2006-06-29 | — | — | US | disclosed |
| US-7037922-B1 | Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands | NEUROGEN CORPORATION (US) | 2006-05-02 | — | — | US | disclosed |
| EP-1165555-B1 | ARYL FUSED 2,4-DISUBSTITUTED PYRIDINES: NK3 RECEPTOR LIGANDS | NEUROGEN CORP (US) | 2003-07-16 | — | — | EP | disclosed |
| EP-1165555-A2 | ARYL FUSED 2,4-DISUBSTITUTED PYRIDINES: NK3 RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000058307-A2 | ARYL FUSED 2,4-DISUBSTITUTED PYRIDINES: NK3 RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2000-10-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142324-A1 | Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands | ACKR3, BDKRB1, GPR3 | SMN1; SMN2 2509/4885LMNA 3130/4885HPGD 2049/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.