Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 10/20 | 0.56 |
| ▸ | CA1 | P00915 | 7/20 | 0.56 |
| ▸ | ACHE | P22303 | 6/20 | 0.56 |
| ▸ | MMP2 | P08253 | 5/20 | 0.55 |
| ▸ | MMP9 | P14780 | 5/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6228483 | 0.78 | PTGS1 (0.72) | PTGS1PTGS2 | |
| SCHEMBL5856805 | 0.72 | PTGS1 (0.74) | PTGS1PTGS2 | |
| SCHEMBL5856591 | 0.71 | PTGS1 (0.67) | PTGS1PTGS2 | |
| SCHEMBL27954382 | 0.70 | MMP2 (0.77) | CA2CA1MMP2MMP9L3MBTL1 | |
| SCHEMBL27991879 | 0.69 | MMP2 (1.00) | MMP2MMP9L3MBTL1PTGS1PTGS2 | |
| SCHEMBL18826385 | 0.69 | L3MBTL1 (0.80) | CA2CA1ACHEMMP2MMP9 | |
| SCHEMBL1069328 | 0.69 | DRD1 (0.64) | CA2CA1PTGS1PTGS2 | |
| SCHEMBL5856582 | 0.69 | PTGS1 (0.69) | PTGS1PTGS2 | |
| SCHEMBL27991839 | 0.68 | MMP2 (0.75) | CA2CA1MMP2MMP9L3MBTL1 | |
| SCHEMBL28810693 | 0.67 | L3MBTL1 (0.79) | CA2CA1ACHEMMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE38963-E1 | Pyrazoline derivatives, their preparation and application as medicaments | LABORATORIOS DEL DR. ESTEVE (ES) | 2006-01-31 | — | — | US | claimed |
| US-6353117-B1 | ANTIINFLAMMATORY ACTIVITY AND DISEASES IN WHICH CYCLOOXYGENASE-2 PLAYS A PART, WITHOUT HAVING THE GASTRIC AND RENAL TOXICITY OF THE CLASSIC NONSTEROIDAL ANTIINFLAMMATORY AGENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2002-03-05 | — | — | US | claimed |