Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5858094 | 0.81 | ALDH1A1 (0.35) | ALDH1A1NPSR1 | |
| SCHEMBL25220979 | 0.80 | CA2 (0.32) | — | |
| SCHEMBL13081648 | 0.74 | TSHR (0.42) | — | |
| SCHEMBL25644072 | 0.74 | — | — | |
| SCHEMBL29285234 | 0.74 | TSHR (0.50) | ALDH1A1 | |
| SCHEMBL779085 | 0.74 | LPAR3 (0.41) | — | |
| SCHEMBL4128068 | 0.72 | LPAR2 (0.31) | — | |
| SCHEMBL779257 | 0.72 | MEN1 (0.35) | — | |
| SCHEMBL11312235 | 0.72 | LPAR2 (0.31) | — | |
| SCHEMBL11309138 | 0.72 | ALDH1A1 (0.48) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049432-B2 | Oligonucleotides having alkylphosphonate linkages and methods for their preparation | ISIS PHARMACEUTICALS, INC. (US) | 2006-05-23 | — | — | US | disclosed |
| US-20030078414-A1 | Oligonucleotides having alkylphosphonate linkages and methods for their preparation | ISIS PHARMACEUTICALS, INC. | 2003-04-24 | — | — | US | disclosed |
| US-6486313-B1 | Oligonucleotides having alkylphosphonate linkages and methods for their preparation | ISIS PHARMACEUTICALS, INC. | 2002-11-26 | — | — | US | disclosed |
| EP-1169329-A4 | OLIGONUCLEOTIDES HAVING ALKYLPHOSPHONATE LINKAGES AND METHODS FOR THEIR PREPARATION | ISIS PHARMACEUTICALS INC (US) | 2002-07-03 | — | — | EP | disclosed |
| EP-1169329-A1 | OLIGONUCLEOTIDES HAVING ALKYLPHOSPHONATE LINKAGES AND METHODS FOR THEIR PREPARATION | ISIS PHARMACEUTICALS, INC. (US) | 2002-01-09 | — | — | EP | disclosed |
| WO-2000049032-A1 | OLIGONUCLEOTIDES HAVING ALKYLPHOSPHONATE LINKAGES AND METHODS FOR THEIR PREPARATION | ISIS PHARMACEUTICALS, INC. (US) | 2000-08-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030078414-A1 | Oligonucleotides having alkylphosphonate linkages and methods for their preparation | POLM, PPIP5K2, POLRMT | ALDH1A1 4446/4885NPSR1 1976/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.