Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | TDO2 | P48775 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.32 |
| ▸ | GCGR | P47871 | 2/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.31 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6582778 | 0.94 | USP2 (0.42) | USP2RAB9AMAPKAPK2IDO1TDO2 | |
| SCHEMBL12062975 | 0.67 | IDO1 (0.44) | IDO1TDO2DPP4DPP8AOC3 | |
| SCHEMBL12052169 | 0.67 | IDO1 (0.44) | IDO1TDO2DPP4DPP8AOC3 | |
| SCHEMBL12052295 | 0.67 | IDO1 (0.44) | IDO1TDO2DPP4DPP8AOC3 | |
| SCHEMBL11682260 | 0.67 | USP2 (0.52) | USP2RAB9AMAPK14GCGRMAPK13 | |
| SCHEMBL330047 | 0.66 | CYP3A4 (0.32) | — | |
| SCHEMBL6000168 | 0.65 | USP2 (0.59) | USP2RAB9AMAPK14GCGRMAPK13 | |
| SCHEMBL6158273 | 0.65 | RAB9A (0.44) | USP2RAB9AMAPK14MAPK13MAPK12 | |
| SCHEMBL2889152 | 0.65 | USP2 (0.44) | USP2RAB9AIDO1MAPK14GCGR | |
| SCHEMBL18945731 | 0.64 | IDO1 (0.41) | IDO1TDO2DPP4AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132544-B2 | Process for the preparation of tetrasubstituted imidazole derivatives and novel crystalline structures thereof | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2006-11-07 | — | — | US | disclosed |
| US-7067671-B2 | Process for the preparation of tetrasubstituted imidazole derivatives and novel crystalline structures thereof | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2006-06-27 | — | — | US | disclosed |
| US-20060030712-A1 | Process for the preparation of tetrasubstituted imidazole derivatives and novel crystalline structures thereof | ZHONG HUA | 2006-02-09 | — | — | US | disclosed |
| EP-1508569-A2 | Process for the preparation of tetrasubstituted imidazole derivatives and novel crystalline structures thereof | Ortho-McNeil Pharmaceutical, Inc. (US) | 2005-02-23 | — | — | EP | disclosed |
| EP-1506966-A2 | Process for the preparation of tetrasubstituted imidazole derivatives and novel crystaline structures thereof | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2005-02-16 | — | — | EP | disclosed |
| EP-1392678-A2 | PROCESS FOR THE PREPARATION OF TETRASUBSTITUTED IMIDAZOLE DERIVATIVES AND NOVEL CRYSTALLINE STRUCTURES THEREOF | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-03-03 | — | — | EP | disclosed |
| US-20030045723-A1 | Process for the preparation of tetrasubstituted imidazole derivatives and novel crystalline structures thereof | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-03-06 | — | — | US | disclosed |
| WO-2002076974-A2 | PROCESS FOR THE PREPARATION OF TETRASUBSTITUTED IMIDAZOLE DERIVATIVES AND NOVEL CRYSTALLINE STRUCTURES THEREOF | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2002-10-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045723-A1 | Process for the preparation of tetrasubstituted imidazole derivatives and novel crystalline structures thereof | CYP4B1, IPO4, RPS4Y1 | USP2 2601/4885RAB9A 771/4885MAPKAPK2 1569/4885 |
| US-20060030712-A1 | Process for the preparation of tetrasubstituted imidazole derivatives and novel crystalline structures thereof | CYP4F3, CYP4F2, CYP4B1 | USP2 2681/4885RAB9A 1096/4885MAPKAPK2 2099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.