Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 20/20 | 0.60 |
| ▸ | THRA | P10827 | 17/20 | 0.60 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4299281 | 0.84 | THRB (0.43) | THRBTHRA | |
| SCHEMBL5858364 | 0.83 | THRB (0.52) | THRBTHRAPPARG | |
| SCHEMBL5278593 | 0.81 | THRB (0.80) | THRBTHRAPPARG | |
| SCHEMBL5074214 | 0.80 | THRB (0.74) | THRBTHRA | |
| SCHEMBL5859452 | 0.79 | THRB (0.62) | THRBTHRAPPARG | |
| SCHEMBL5858371 | 0.78 | THRB (0.78) | THRBTHRAPPARG | |
| SCHEMBL4299815 | 0.78 | THRB (0.45) | THRBTHRA | |
| SCHEMBL3908141 | 0.78 | THRA (0.49) | THRBTHRA | |
| SCHEMBL5280260 | 0.76 | THRB (0.68) | THRBTHRAPPARG | |
| SCHEMBL3910551 | 0.76 | THRA (0.41) | THRBTHRAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144909-B2 | Phenoxy substituted benzocondensed heteroaryl derivatives as thyroid receptor ligands | KARO BIO AB (SE) | 2006-12-05 | — | — | US | disclosed |
| US-20040116387-A1 | Phenoxy substituted benzocondensed heteroaryl derivatives as thyroid receptor ligands | KARO BIO AB (SE) | 2004-06-17 | — | — | US | disclosed |