Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 7/20 | 0.43 |
| ▸ | THRB | P10828 | 7/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.43 |
| ▸ | CDC42 | P60953 | 1/20 | 0.43 |
| ▸ | RAC1 | P63000 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7116014 | 0.89 | THRA (0.40) | THRATHRBCYP1A2CYP2C19 | |
| SCHEMBL5363051 | 0.85 | THRB (0.58) | THRATHRB | |
| SCHEMBL5861511 | 0.85 | THRB (0.52) | THRATHRBCYP1A2TSHRPPARG | |
| SCHEMBL5858142 | 0.85 | FFAR1 (0.44) | THRATHRBCYP1A2PPARG | |
| SCHEMBL5858288 | 0.83 | PTGS2 (0.54) | THRATHRBPTGS2PTGS1AKR1C3 | |
| SCHEMBL5858138 | 0.82 | THRB (0.49) | THRATHRBTSHRPPARG | |
| SCHEMBL7125355 | 0.80 | MEN1 (0.45) | THRATHRBCYP1A2TSHRPPARG | |
| SCHEMBL5858756 | 0.79 | THRB (0.62) | THRATHRBCYP1A2PPARG | |
| SCHEMBL5858136 | 0.78 | THRB (0.39) | THRATHRBAKR1C3AKR1C2CYP1A2 | |
| SCHEMBL5964846 | 0.78 | THRA (0.48) | THRATHRBPTGS2PTGS1AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144909-B2 | Phenoxy substituted benzocondensed heteroaryl derivatives as thyroid receptor ligands | KARO BIO AB (SE) | 2006-12-05 | — | — | US | disclosed |
| US-20040116387-A1 | Phenoxy substituted benzocondensed heteroaryl derivatives as thyroid receptor ligands | KARO BIO AB (SE) | 2004-06-17 | — | — | US | disclosed |