Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 8/20 | 0.40 |
| ▸ | THRB | P10828 | 8/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5859459 | 0.89 | THRA (0.43) | THRATHRBCYP1A2CYP2C19 | |
| SCHEMBL7116655 | 0.87 | THRB (0.47) | THRATHRBMEN1KMT2ACYP1A2 | |
| SCHEMBL7050847 | 0.86 | THRB (0.54) | THRATHRB | |
| SCHEMBL7115995 | 0.83 | TDP1 (0.43) | THRATHRBMEN1KMT2ACYP1A2 | |
| SCHEMBL5858142 | 0.81 | FFAR1 (0.44) | THRATHRBCYP1A2CYP2C9 | |
| SCHEMBL7125355 | 0.79 | MEN1 (0.45) | THRATHRBMEN1KMT2ACYP1A2 | |
| SCHEMBL7255051 | 0.77 | THRB (0.48) | THRATHRBCYP1A2CYP2C9 | |
| SCHEMBL5858138 | 0.77 | THRB (0.49) | THRATHRBMEN1KMT2A | |
| SCHEMBL5858756 | 0.76 | THRB (0.62) | THRATHRBCYP1A2CYP2C9 | |
| SCHEMBL2742620 | 0.75 | ALDH1A1 (0.51) | MEN1KMT2ACYP1A2CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358175-A2 | PHENOXY SUBSTITUTED BENZOCONDENSED HETEROARYL DERIVATIVES AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002062780-A2 | PHENOXY SUBSTITUTED BENZOCONDENSED HETEROARYL DERIVATIVES AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2002-08-15 | — | — | WO | disclosed |