Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAM | P19021 | 3/20 | 0.63 |
| ▸ | TSHR | P16473 | 4/20 | 0.56 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.42 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRR2 | P28476 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10578392 | 0.95 | PAM (0.69) | PAMTSHRSLC22A6LMNANFKB1 | |
| SCHEMBL1712357 | 0.93 | PAM (0.73) | PAMTSHRSLC22A6LMNANFKB1 | |
| SCHEMBL27730313 | 0.93 | PAM (0.73) | PAMTSHRSLC22A6LMNANFKB1 | |
| SCHEMBL1845834 | 0.90 | PAM (0.75) | PAMTSHRSLC22A6LMNANFKB1 | |
| SCHEMBL1845790 | 0.87 | PAM (0.79) | PAMTSHRSLC22A6LMNANFKB1 | |
| SCHEMBL27697262 | 0.87 | PAM (0.79) | PAMTSHRSLC22A6LMNANFKB1 | |
| SCHEMBL27714306 | 0.87 | PAM (0.79) | PAMTSHRSLC22A6LMNANFKB1 | |
| SCHEMBL11956805 | 0.85 | PAM (0.69) | PAMTSHRSLC22A6LMNANFKB1 | |
| SCHEMBL530330 | 0.84 | PAM (0.56) | PAMTSHRSLC22A6LMNANFKB1 | |
| SCHEMBL9558119 | 0.84 | SLC22A6 (0.61) | PAMTSHRSLC22A6LMNANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150283092-A1 | DRUG DELIVERY COMPOSITION | ALKERMES PHARMA IRELAND LTD (IE) | 2015-10-08 | — | — | US | disclosed |
| EP-2416764-A1 | DRUG DELIVERY COMPOSITION | Alkermes Pharma Ireland Limited (IE) | 2012-02-15 | — | — | EP | disclosed |
| EP-2416782-A1 | CONTROLLED-RELEASE CLOZAPINE COMPOSITIONS | Alkermes Pharma Ireland Limited (IE) | 2012-02-15 | — | — | EP | disclosed |
| US-20100260858-A1 | DRUG DELIVERY COMPOSITION | ELAN PHARMA INTERNATIONAL LIMITED (IE) | 2010-10-14 | — | — | US | disclosed |
| US-20100260859-A1 | CONTROLLED-RELEASE CLOZAPINE COMPOSITIONS | ELAN PHARMA INTERNATIONAL LIMITED (IE) | 2010-10-14 | — | — | US | disclosed |
| WO-2010118232-A1 | CONTROLLED-RELEASE CLOZAPINE COMPOSITIONS | ELAN PHARMA INTERNATIONAL LIMITED (IE) | 2010-10-14 | — | — | WO | disclosed |
| WO-2010118228-A1 | DRUG DELIVERY COMPOSITION | ELAN PHARMA INTERNATIONAL LIMITED (IE) | 2010-10-14 | — | — | WO | disclosed |
| EP-1227800-A1 | OSMOTIC CONTROLLED RELEASE DRUG DELIVERY DEVICE | Merck & Co., Inc. (US) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001032149-A1 | OSMOTIC CONTROLLED RELEASE DRUG DELIVERY DEVICE | MERCK & CO., INC. (US) | 2001-05-10 | — | — | WO | disclosed |