Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL607557 | 0.79 | ALDH1A1 (0.65) | LMNAGAAL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL609919 | 0.74 | ALDH1A1 (0.42) | GAAALDH1A1KDM4EKMT2APOLB | |
| SCHEMBL228778 | 0.72 | ALDH1A1 (0.61) | LMNAGAAL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL29671348 | 0.72 | ALDH1A1 (0.61) | LMNAGAAL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL1740547 | 0.72 | NPC1 (0.66) | LMNAGAAL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL7825774 | 0.72 | LMNA (0.57) | LMNAGAAL3MBTL1ALDH1A1KDM4E | |
| Lithium SCHEMBL31310856 | 0.71 | ALDH1A1 (0.59) | LMNAGAAL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL702149 | 0.71 | ALDH1A1 (0.59) | LMNAGAAL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL4975521 | 0.71 | HCRTR1 (0.41) | CYP2C19CYP2C9CYP1A2 | |
| SCHEMBL1520747 | 0.71 | ALDH1A1 (1.00) | LMNAGAAL3MBTL1ALDH1A1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7034018-B2 | Substituted pyrrole mannich bases to combat pain and allergic reactions | GRUENENTHAL GMBH (DE) | 2006-04-25 | — | — | US | disclosed |
| EP-1246799-B1 | SUBSTITUTED PYRROLE MANNICH BASES TO COMBAT PAIN AND ALLERGIC REACTIONS | GRUENENTHAL GMBH (DE) | 2003-10-15 | — | — | EP | disclosed |
| US-20030023100-A1 | Substituted pyrrole mannich bases to combat pain and allergic reactions | GRUENENTHAL GMBH (DE) | 2003-01-30 | — | — | US | disclosed |
| EP-1246799-A1 | SUBSTITUTED PYRROLE MANNICH BASES TO COMBAT PAIN AND ALLERGIC REACTIONS | Grünenthal GmbH (DE) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001047878-A1 | SUBSTITUTED PYRROLE MANNICH BASES TO COMBAT PAIN AND ALLERGIC REACTIONS | Grünenthal GmbH (DE) | 2001-07-05 | — | — | WO | disclosed |
| WO-2001047882-A2 | SUBSTANCE LIBRARY WHICH CAN BE OBTAINED BY REACTING ALDEHYDES WITH SECONDARY AMINES, ACID CHLORIDES AND NAPHTHOL, PYRROLE AND/OR INDOLE COMPOUNDS | Grünenthal GmbH (DE) | 2001-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030023100-A1 | Substituted pyrrole mannich bases to combat pain and allergic reactions | CRHR1, CNR1, CRHR2 | LMNA 4289/4885GAA 487/4885L3MBTL1 797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.