Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of 2-Methoxyethanol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Methoxyethanol SCHEMBL997154 | 0.94 | — | — | |
| 2-Methoxyethanol SCHEMBL8327328 | 0.90 | ALDH1A1 (0.45) | ALDH1A1TSHRMAPK1MEN1KMT2A | |
| 2-Methoxyethanol SCHEMBL27490327 | 0.90 | — | — | |
| 2-Methoxyethanol SCHEMBL6553739 | 0.88 | ALDH1A1 (0.43) | ALDH1A1TSHRMAPK1MEN1KMT2A | |
| 2-Methoxyethanol SCHEMBL2789723 | 0.87 | — | — | |
| 2-Methoxyethanol SCHEMBL1317307 | 0.87 | TSHR (0.47) | ALDH1A1TSHRMAPK1MEN1KMT2A | |
| 2-Methoxyethanol SCHEMBL310 | 0.87 | — | — | |
| 2-Methoxyethanol SCHEMBL4885313 | 0.84 | — | — | |
| 2-Methoxyethanol SCHEMBL28182844 | 0.84 | — | — | |
| 2-Methoxyethanol SCHEMBL2678565 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040232468-A1 | Barrier layers for protecting metal oxides from hydrogen degradation | SYMETRIX CORPORATION | 2004-11-25 | — | — | US | claimed |
| US-20030098497-A1 | Barrier layers for protecting metal oxides from hydrogen degradation | SYMETRIX CORPORATION | 2003-05-29 | — | — | US | claimed |
| US-7064374-B2 | Barrier layers for protecting metal oxides from hydrogen degradation | SYMETRIX CORPORATION (US) | 2006-06-20 | — | — | US | disclosed |
| US-20040232468-A1 | Barrier layers for protecting metal oxides from hydrogen degradation | SYMETRIX CORPORATION | 2004-11-25 | — | — | US | disclosed |
| US-6781184-B2 | Barrier layers for protecting metal oxides from hydrogen degradation | SYMETRIX CORPORATION | 2004-08-24 | — | — | US | disclosed |
| US-20030098497-A1 | Barrier layers for protecting metal oxides from hydrogen degradation | SYMETRIX CORPORATION | 2003-05-29 | — | — | US | disclosed |