2-Methoxyethanol — predicted protein targets

Known targets — ChEMBL curated mechanism

MMP1 MMP13 MMP7 MMP8 pol rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of 2-Methoxyethanol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	ALDH1A1	P00352	2/20	0.43

▸	TSHR	P16473	3/20	0.38

▸	MAPK1	P28482	1/20	0.37

▸	MEN1	O00255	2/20	0.35

▸	KMT2A	Q03164	2/20	0.35

▸	THRB	P10828	1/20	0.33

▸	HTT	P42858	1/20	0.33

▸	MAPT	P10636	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
2-Methoxyethanol SCHEMBL997154	0.94	—	—
2-Methoxyethanol SCHEMBL5091016	0.94	TSHR (0.41)	ALDH1A1TSHRMAPK1MEN1KMT2A
2-Methoxyethanol SCHEMBL2915239	0.94	TSHR (0.41)	ALDH1A1TSHRMAPK1MEN1KMT2A
2-Methoxyethanol SCHEMBL1482714	0.94	—	—
2-Methoxyethanol SCHEMBL851952	0.94	TSHR (0.41)	ALDH1A1TSHRMAPK1MEN1KMT2A
2-Methoxyethanol SCHEMBL17351933	0.94	TSHR (0.41)	ALDH1A1TSHRMAPK1MEN1KMT2A
2-Methoxyethanol SCHEMBL6268627	0.94	TSHR (0.41)	ALDH1A1TSHRMAPK1MEN1KMT2A
2-Methoxyethanol SCHEMBL3548931	0.94	TSHR (0.41)	ALDH1A1TSHRMAPK1MEN1KMT2A
2-Methoxyethanol SCHEMBL21641729	0.94	TSHR (0.41)	ALDH1A1TSHRMAPK1MEN1KMT2A
2-Methoxyethanol SCHEMBL17351943	0.94	TSHR (0.41)	ALDH1A1TSHRMAPK1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-6770267-B2	Methods of treating periodontal disease	SMITHKLINE BEECHAM CORPORATION	2004-08-03	—	—	US	disclosed
US-20040034020-A1	Methods of treating periodontal disease	DALUGE SUSAN MARY (US)	2004-02-19	—	—	US	disclosed
EP-1104422-B1	PHENYL XANTHINE DERIVATIVES	GLAXO GROUP LTD (GB)	2004-02-18	—	—	EP	disclosed
US-6608069-B1	Treating AIDS-related diarrhea or infectious diarrhea, tissue damage or dermatitis associated with leukocyte infiltration into tissue, asthma, inflammatory bowel condition, eczema, or psoriasis	SMITHKLINE BEECHAM CORPORATION	2003-08-19	—	—	US	disclosed
US-20030032804-A1	Methods of treating periodontal disease	SMITHKLINE BEECHAM CORPORATION	2003-02-13	—	—	US	disclosed
EP-1104422-A1	PHENYL XANTHINE DERIVATIVES	GLAXO GROUP LIMITED (GB)	2001-06-06	—	—	EP	disclosed
WO-2000009507-A1	PHENYL YANTHINE DERIVATIVES	GLAXO GROUP LIMITED (GB)	2000-02-24	—	—	WO	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20040034020-A1	Methods of treating periodontal disease	MMP8, LPO, PTGES3	ALDH1A1 2314/4885TSHR 3131/4885MAPK1 4794/4885
US-20030032804-A1	Methods of treating periodontal disease	HPGDS, SELP, ALPI	ALDH1A1 2569/4885TSHR 3123/4885MAPK1 2833/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.