Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of 2-Methoxyethanol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Methoxyethanol SCHEMBL997154 | 0.97 | — | — | |
| 2-Methoxyethanol SCHEMBL8727425 | 0.93 | — | — | |
| 2-Methoxyethanol SCHEMBL7944654 | 0.93 | TSHR (0.44) | ALDH1A1TSHRMAPK1MEN1KMT2A | |
| 2-Methoxyethanol SCHEMBL27456540 | 0.93 | TSHR (0.44) | ALDH1A1TSHRMAPK1MEN1KMT2A | |
| 2-Methoxyethanol SCHEMBL5859982 | 0.90 | ALDH1A1 (0.43) | ALDH1A1TSHRMAPK1MEN1KMT2A | |
| 2-Methoxyethanol SCHEMBL6553739 | 0.90 | ALDH1A1 (0.43) | ALDH1A1TSHRMAPK1MEN1KMT2A | |
| 2-Methoxyethanol SCHEMBL2789723 | 0.90 | — | — | |
| 2-Methoxyethanol SCHEMBL1317307 | 0.89 | TSHR (0.47) | ALDH1A1TSHRMAPK1MEN1KMT2A | |
| 2-Methoxyethanol SCHEMBL310 | 0.89 | — | — | |
| 2-Methoxyethanol SCHEMBL4885313 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6003987-A | Ink set recording apparatus and method using ink set having a dye that becomes insoluble when mixed with another dye | CANON KABUSHIKI KAISHA (JP) | 1999-12-21 | — | — | US | disclosed |
| US-4661643-A | USING RUTHENIUM CATALYST | UNION CARBIDE CORPORATION (US) | 1987-04-28 | — | — | US | disclosed |
| EP-0075952-A1 | Hydrogenolysis process for the production of monoethylene glycol monomethyl ether, monoethylene glycol and ethanol | UNION CARBIDE CORPORATION (US) | 1983-04-06 | — | — | EP | disclosed |
| EP-0075936-A1 | A process for selectively producing monoethylene glycol monomethyl ether with the simultaneous coproduction of monoethylene glycol and ethanol | UNION CARBIDE CORPORATION (US) | 1983-04-06 | — | — | EP | disclosed |