Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | USP7 | Q93009 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | FPR3 | P25089 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18588873 | 0.75 | ALDH1A1 (0.44) | ALDH1A1CCNE1CDK2CDK5USP7 | |
| SCHEMBL6127287 | 0.74 | ALDH1A1 (0.42) | ALDH1A1CCNE1CDK2CDK5USP7 | |
| SCHEMBL30911709 | 0.73 | FYN (0.42) | ALDH1A1SMN1; SMN2CYP3A4CYP2C19KDM4E | |
| SCHEMBL1706134 | 0.73 | CCNE1 (0.47) | ALDH1A1CCNE1CDK2CDK5USP7 | |
| SCHEMBL2817969 | 0.72 | MAPT (0.38) | ALDH1A1CCNE1CDK2CDK5USP7 | |
| SCHEMBL27939524 | 0.72 | RAB9A (0.37) | ALDH1A1CCNE1CDK2CDK5USP7 | |
| SCHEMBL2332707 | 0.72 | USP7 (0.35) | ALDH1A1CCNE1CDK2CDK5USP7 | |
| SCHEMBL27259611 | 0.71 | ALDH1A1 (0.41) | ALDH1A1CCNE1CDK2CDK5USP7 | |
| SCHEMBL21332912 | 0.71 | CCNE1 (0.56) | ALDH1A1CCNE1CDK2CDK5RAB9A | |
| SCHEMBL19014339 | 0.70 | ALDH1A1 (0.40) | ALDH1A1CCNE1CDK2CDK5USP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7138403-B2 | 2,4,5-trisubstituted thiazolyl derivatives and their antiinflammatory activity | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-11-21 | — | — | US | disclosed |
| US-20040254192-A1 | 2,4,5-trisubstituded thiazolyl derivatives and their antiinflammatory activity | KEY ORGANICS LTD. (GB) | 2004-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254192-A1 | 2,4,5-trisubstituded thiazolyl derivatives and their antiinflammatory activity | IL6, TNF, IL1B | ALDH1A1 2394/4885CCNE1 3016/4885CDK2 2988/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.