Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 5/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.51 |
| ▸ | CTSK | P43235 | 3/20 | 0.51 |
| ▸ | CTSS | P25774 | 1/20 | 0.51 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15165758 | 1.00 | KEAP1 (0.51) | KEAP1NFE2L2CTSKCTSSGABRB1 | |
| SCHEMBL1573516 | 1.00 | KEAP1 (0.51) | KEAP1NFE2L2CTSKCTSSGABRB1 | |
| SCHEMBL13079942 | 0.90 | CTSK (0.50) | KEAP1NFE2L2CTSKCTSSGABRB1 | |
| SCHEMBL26647713 | 0.88 | CTSS (0.47) | KEAP1NFE2L2CTSKCTSSMAPT | |
| SCHEMBL8295708 | 0.88 | CTSK (0.53) | CTSKCTSSGABRB1GABRB2MAPT | |
| SCHEMBL12993554 | 0.88 | CTSK (0.53) | CTSKCTSSGABRB1GABRB2MAPT | |
| SCHEMBL23205818 | 0.87 | PPARG (0.47) | KEAP1NFE2L2CTSKCTSSMAPT | |
| SCHEMBL5862822 | 0.87 | PPARG (0.47) | KEAP1NFE2L2CTSKCTSSMAPT | |
| SCHEMBL20521905 | 0.87 | PPARG (0.47) | KEAP1NFE2L2CTSKCTSSMAPT | |
| SCHEMBL6513379 | 0.87 | KEAP1 (0.42) | KEAP1NFE2L2CTSKCTSSPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7041667-B1 | CCR5 modulators | PFIZER, INC. (US) | 2006-05-09 | — | — | US | disclosed |