Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 2/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5863237 | 1.00 | AOC3 (0.47) | AOC3GPR119ALDH1A1HPGDLMNA | |
| SCHEMBL6858656 | 0.84 | MEN1 (0.47) | GPR119MEN1GFERKMT2AROCK2 | |
| SCHEMBL782021 | 0.84 | MEN1 (0.47) | GPR119MEN1GFERKMT2AROCK2 | |
| SCHEMBL6626168 | 0.84 | MEN1 (0.47) | GPR119MEN1GFERKMT2AROCK2 | |
| SCHEMBL14830816 | 0.82 | MEN1 (0.47) | GPR119ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL3978842 | 0.81 | CYP3A4 (0.60) | ALDH1A1LMNAMAPTKDM4EMEN1 | |
| SCHEMBL6645521 | 0.81 | CYP3A4 (0.60) | ALDH1A1LMNAMAPTKDM4EMEN1 | |
| SCHEMBL5378296 | 0.80 | ROCK2 (0.44) | GPR119ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL5863130 | 0.78 | KCNQ3 (0.71) | AOC3ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL5863139 | 0.78 | KCNQ3 (0.71) | AOC3ALDH1A1LMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087609-B2 | 3-(pyridinyl-piperazin-1-yl)-phenylethyl amides as potassium channel openers | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-08-08 | — | — | US | disclosed |
| US-20040110765-A1 | 3-(Pyridinyl-piperazin-1-yl)-phenylethyl amides as potassium channel openers | BRISTOL-MYERS SQUIBB COMPANY | 2004-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110765-A1 | 3-(Pyridinyl-piperazin-1-yl)-phenylethyl amides as potassium channel openers | KCNQ3, KCNQ1, KCNQ2 | AOC3 3804/4885GPR119 1404/4885ALDH1A1 808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.