Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAUR | Q03405 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MASP2 | O00187 | 1/20 | 0.43 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | KHK | P50053 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2260824 | 0.92 | AURKA (0.42) | PLAURKDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL11150161 | 0.73 | ALDH1A1 (0.50) | PLAURKDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL11150961 | 0.72 | ALDH1A1 (0.42) | PLAURKDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL1624786 | 0.68 | NUDT1 (0.48) | KDM4ENUDT1FGFR1AURKACDK9 | |
| SCHEMBL3860291 | 0.67 | NPC1 (0.49) | KDM4EALDH1A1RAB9ANPC1HSD17B10 | |
| SCHEMBL11841393 | 0.67 | MAPT (0.45) | PLAURKDM4ERAB9ANPC1HSD17B10 | |
| SCHEMBL37862 | 0.67 | ALDH1A1 (0.59) | PLAURKDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL29396007 | 0.67 | ALDH1A1 (0.59) | PLAURKDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL5477868 | 0.65 | MAPT (0.53) | PLAURKDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL11129386 | 0.65 | ALDH1A1 (0.57) | PLAURKDM4EALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021188055-A1 | MODULATION OF CXCR3 CHEMOKINE SIGNALLING FOR OSTEOPOROSIS THERAPY | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2021-09-23 | — | — | WO | claimed |
| CN-112679423-A | Amination reagent and synthesis method and application thereof | 中南大学 | 2021-04-20 | — | — | CN | claimed |
| US-11739071-B2 | Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors | VALO HEALTH, INC. (US) | 2023-08-29 | — | — | US | disclosed |
| CN-110022881-B | Inhibitors of CD 73-mediated immunosuppression | 艾库斯生物科学有限公司 | 2023-05-02 | — | — | CN | disclosed |
| EP-3746432-B1 | 4-HYDROXYPIPERIDINE DERIVATIVES AND THEIR USE AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 19 (USP19) | ALMAC DISCOVERY LTD (GB) | 2022-12-14 | — | — | EP | disclosed |
| US-20220125760-A1 | USE OF USP7 INHIBITORS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA (AML) | UNIVERSITÉ PAUL SABATIER TOULOUSE III (FR) | 2022-04-28 | — | — | US | disclosed |
| CN-112679423-B | Amination reagent and synthesis method and application thereof | 中南大学 | 2022-04-26 | — | — | CN | disclosed |
| CN-112679423-B | Amination reagent and synthesis method and application thereof | 中南大学 | 2022-04-26 | — | — | CN | disclosed |
| CN-113461686-B | Fluorescent probe, preparation method and application thereof, and fluorescent probe solution | 中国农业大学 | 2022-03-29 | — | — | CN | disclosed |
| EP-3923987-A1 | USE OF USP7 INHIBITORS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA (AML) | Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) | 2021-12-22 | — | — | EP | disclosed |
| WO-2021188055-A1 | MODULATION OF CXCR3 CHEMOKINE SIGNALLING FOR OSTEOPOROSIS THERAPY | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2021-09-23 | — | — | WO | disclosed |
| WO-2005065183-A2 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2005-07-21 | — | — | WO | disclosed |
| EP-1517904-A2 | MITOTIC KINESIN INHIBITORS | Merck & Co., Inc. (US) | 2005-03-30 | — | — | EP | disclosed |
| EP-1517904-A2 | MITOTIC KINESIN INHIBITORS | Merck & Co., Inc. (US) | 2005-03-30 | — | — | EP | disclosed |
| WO-2004039774-A3 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2004-07-01 | — | — | WO | disclosed |
| WO-2004039774-A2 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2004-05-13 | — | — | WO | disclosed |
| WO-2004039774-A2 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2004-05-13 | — | — | WO | disclosed |
| WO-2001010860-A2 | QUINAZOLINONE AND AZAQUINAZOLINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-02-15 | — | — | WO | disclosed |
| US-5424311-A | A viricides for treating viral diseases; HIV enzyme inhibitor | HOESCHST AKTIENGESELLSCHAFT (DE) | 1995-06-13 | — | — | US | disclosed |
| US-4000275-A | BENZIMIDAZO(2,1-B) QUINAZOLIN-12(6H)ONES | ELI LILLY AND COMPANY (US) | 1976-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11739071-B2 | Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors | USP7, UBQLN1, UBA7 | PLAUR 2687/4885KDM4E 360/4885ALDH1A1 2483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.