Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 3/20 | 0.53 |
| ▸ | MMP1 | P03956 | 2/20 | 0.47 |
| ▸ | MMP9 | P14780 | 2/20 | 0.47 |
| ▸ | MMP13 | P45452 | 2/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 8/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5863929 | 0.92 | PGR (0.54) | PGRLTA4HMMP1MMP9MMP13 | |
| SCHEMBL5863875 | 0.92 | LTA4H (0.47) | LTA4HMMP1MMP9MMP13ADAM17 | |
| SCHEMBL5863850 | 0.89 | MMP1 (0.51) | PGRLTA4HMMP1MMP9MMP13 | |
| SCHEMBL5863969 | 0.89 | ESR1 (0.49) | LTA4HMMP1MMP9MMP13ADAM17 | |
| SCHEMBL5863972 | 0.89 | LTA4H (0.48) | PGRLTA4HMMP1MMP9MMP13 | |
| SCHEMBL5863802 | 0.89 | LTA4H (0.54) | PGRLTA4HMMP1MMP9MMP13 | |
| SCHEMBL5863970 | 0.89 | ESR1 (0.54) | LTA4HMMP1MMP9MMP13ADAM17 | |
| SCHEMBL5864177 | 0.88 | MMP1 (0.54) | LTA4HMMP1MMP9MMP13ADAM17 | |
| SCHEMBL5864065 | 0.87 | LTA4H (0.52) | LTA4HMMP1MMP9MMP13ADAM17 | |
| SCHEMBL5863824 | 0.85 | LTA4H (0.47) | LTA4HKCNH2MCHR1ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7053212-B2 | Acyclic amide and sulfonamide ligands for the estrogen receptor | PFIZER INC. (US) | 2006-05-30 | — | — | US | disclosed |
| US-20040110767-A1 | Acyclic amide and sulfonamide ligands for the estrogen receptor | PFIZER INC | 2004-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110767-A1 | Acyclic amide and sulfonamide ligands for the estrogen receptor | GHSR, GPER1, SSTR1 | PGR 54/4885LTA4H 1687/4885MMP1 1746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.