Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SLC16A1 | P53985 | 12/20 | 0.42 |
| ▸ | PARG | Q86W56 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5864761 | 0.89 | SLC16A1 (0.42) | SLC16A1PARG | |
| SCHEMBL5864744 | 0.87 | PDE3B (0.47) | ADORA2AADORA2BADORA1SLC16A1PARG | |
| SCHEMBL5864669 | 0.85 | PDE1B (0.47) | SLC16A1LMNASMN1; SMN2 | |
| SCHEMBL5864716 | 0.81 | PDE1B (0.41) | SLC16A1SMN1; SMN2 | |
| SCHEMBL5864728 | 0.80 | POLB (0.43) | ADORA2AADORA2BADORA1POLBSLC16A1 | |
| SCHEMBL7008583 | 0.80 | TBXAS1 (0.42) | SLC16A1PARG | |
| SCHEMBL7011267 | 0.79 | PDE1B (0.39) | ADORA1SLC16A1 | |
| SCHEMBL5864838 | 0.79 | ALDH1A1 (0.41) | ADORA1POLBSLC16A1PARGLMNA | |
| SCHEMBL6752243 | 0.78 | SLC16A1 (0.51) | SLC16A1 | |
| SCHEMBL7010765 | 0.77 | SLC16A1 (0.38) | ADORA2AADORA2BADORA1SLC16A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984644-B2 | Treatment of skin disorders using thieno[2,3-D]pyrimidinediones | ASTRAZENECA AB (SE) | 2006-01-10 | — | — | US | claimed |
| US-6469014-B1 | IMMUNOSUPPRESSIVE ACTIVITY | ASTRAZENECA AB (SE) | 2002-10-22 | — | — | US | claimed |
| EP-0991653-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2002-10-16 | — | — | EP | claimed |
| US-6984644-B2 | Treatment of skin disorders using thieno[2,3-D]pyrimidinediones | ASTRAZENECA AB (SE) | 2006-01-10 | — | — | US | disclosed |
| US-6469014-B1 | IMMUNOSUPPRESSIVE ACTIVITY | ASTRAZENECA AB (SE) | 2002-10-22 | — | — | US | disclosed |