Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 4/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.41 |
| ▸ | PDE1A | P54750 | 3/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.41 |
| ▸ | PDE2A | O00408 | 2/20 | 0.41 |
| ▸ | PARG | Q86W56 | 1/20 | 0.39 |
| ▸ | SLC16A1 | P53985 | 5/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.37 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7011267 | 0.87 | PDE1B (0.39) | PDE1BPDE1APDE1CPDE2ASLC16A1 | |
| SCHEMBL5864669 | 0.87 | PDE1B (0.47) | PDE1BPDE1APDE1CPDE2ASLC16A1 | |
| SCHEMBL5864744 | 0.82 | PDE3B (0.47) | PDE1BPDE1APDE1CPDE2APARG | |
| SCHEMBL5864889 | 0.81 | SLC16A1 (0.42) | PDE1BPDE1APDE1CPDE2ASLC16A1 | |
| SCHEMBL5864838 | 0.81 | ALDH1A1 (0.41) | PDE1BPDE1APDE1CPDE2APARG | |
| SCHEMBL7006986 | 0.80 | SLC16A1 (0.43) | PDE1BPDE1APDE1CPDE2APARG | |
| SCHEMBL5865074 | 0.80 | PARG (0.41) | PDE1BPDE1APDE1CPDE2APARG | |
| SCHEMBL5865280 | 0.80 | ADORA2A (0.44) | PARGSLC16A1 | |
| SCHEMBL7009074 | 0.80 | TSHR (0.39) | PDE1BPDE1APDE1CPDE2ASLC16A1 | |
| SCHEMBL5864716 | 0.79 | PDE1B (0.41) | PDE1BPDE1APDE1CPDE2ASLC16A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107973-B1 | NOVEL THIENO[2,3-d]PYRIMIDINEDIONES, PROCESS FOR THEIR PREPARATION AND USE THEREOF IN THERAPY | ASTRAZENECA AB (SE) | 2003-11-05 | — | — | EP | claimed |
| US-6300334-B1 | DRUGS FOR TREATMENT OF RESPIRATORY SYSTEM DISORDERS | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | claimed |
| EP-1107973-B1 | NOVEL THIENO[2,3-d]PYRIMIDINEDIONES, PROCESS FOR THEIR PREPARATION AND USE THEREOF IN THERAPY | ASTRAZENECA AB (SE) | 2003-11-05 | — | — | EP | disclosed |
| US-6300334-B1 | DRUGS FOR TREATMENT OF RESPIRATORY SYSTEM DISORDERS | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | disclosed |
| EP-1107973-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012514-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-03-09 | — | — | WO | disclosed |