Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL581826 | 0.97 | RIPK1 (0.42) | RIPK1BRD4SMN1; SMN2NPC1RAB9A | |
| SCHEMBL581935 | 0.97 | RIPK1 (0.42) | RIPK1BRD4SMN1; SMN2NPC1RAB9A | |
| SCHEMBL581827 | 0.97 | RIPK1 (0.42) | RIPK1BRD4SMN1; SMN2NPC1RAB9A | |
| SCHEMBL582438 | 0.88 | ALDH1A1 (0.36) | SMN1; SMN2MEN1KMT2AGAATSHR | |
| SCHEMBL581727 | 0.88 | NOTUM (0.38) | SMN1; SMN2KDM4EGAAALDH1A1 | |
| SCHEMBL581726 | 0.88 | NOTUM (0.38) | SMN1; SMN2KDM4EGAAALDH1A1 | |
| SCHEMBL582439 | 0.88 | ALDH1A1 (0.36) | SMN1; SMN2MEN1KMT2AGAATSHR | |
| SCHEMBL587487 | 0.88 | ALDH1A1 (0.38) | RIPK1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL581796 | 0.87 | ALDH1A1 (0.47) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL581795 | 0.87 | ALDH1A1 (0.47) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |