Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | IDH2 | P48735 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | UBE2M | P61081 | 1/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GUSB | P08236 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | USP5 | P45974 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL586920 | 0.96 | MAPT (0.42) | NOTUMTDP1MAPTUBE2MDCUN1D1 | |
| SCHEMBL580827 | 0.96 | NOTUM (0.48) | NOTUMIDH2TDP1UBE2MDCUN1D1 | |
| SCHEMBL586674 | 0.88 | NOTUM (0.44) | NOTUMTDP1MAPTKDM4ESLC6A9 | |
| SCHEMBL587031 | 0.86 | RIPK1 (0.36) | MAPTKMT2AALDH1A1MEN1HPGD | |
| SCHEMBL581709 | 0.86 | RIPK1 (0.39) | NOTUMKMT2AALDH1A1MEN1 | |
| SCHEMBL587057 | 0.86 | TACR1 (0.40) | NOTUMIDH2TDP1MAPT | |
| SCHEMBL581795 | 0.85 | ALDH1A1 (0.47) | NOTUMIDH2LMNAKMT2AALDH1A1 | |
| SCHEMBL581796 | 0.85 | ALDH1A1 (0.47) | NOTUMIDH2LMNAKMT2AALDH1A1 | |
| SCHEMBL581556 | 0.84 | NOTUM (0.53) | NOTUMIDH2KDM4ESLC6A9KMT2A | |
| SCHEMBL582132 | 0.83 | NOTUM (0.47) | NOTUMTDP1KDM4ESLC6A9EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |