Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MGLL | Q99685 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | TRPV6 | Q9H1D0 | 2/20 | 0.37 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.37 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.37 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5867429 | 0.81 | MGLL (0.59) | KDM4EMGLLKIF11TRPV6ORAI1 | |
| SCHEMBL28769064 | 0.76 | MGLL (0.47) | MGLLMAPTNPSR1XBP1TRPV6 | |
| SCHEMBL5546389 | 0.76 | KIF11 (0.47) | KDM4EMAPTNPSR1XBP1KIF11 | |
| SCHEMBL29632676 | 0.75 | MAPT (0.53) | MAPTNPSR1XBP1CES2MEN1 | |
| SCHEMBL496276 | 0.75 | MAPT (0.53) | MAPTNPSR1XBP1CES2MEN1 | |
| SCHEMBL31395130 | 0.73 | APP (0.46) | MAPTNPSR1XBP1KIF11MEN1 | |
| SCHEMBL5840 | 0.72 | KDM4E (1.00) | KDM4ECA1CA2 | |
| Methane SCHEMBL28841002 | 0.70 | KDM4E (0.95) | KDM4ECA1CA2 | |
| SCHEMBL28202653 | 0.70 | KDM4E (0.95) | KDM4ECA1CA2 | |
| SCHEMBL138245 | 0.69 | TAS2R14 (0.39) | MAPTNPSR1XBP1CES2KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |