Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 17/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 14/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | KLF10 | Q13118 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5869168 | 1.00 | SLC6A2 (0.44) | SLC6A2SLC6A4PMP22CYP1A2CYP3A4 | |
| SCHEMBL5869717 | 0.83 | SLC6A4 (0.39) | SLC6A2SLC6A4PMP22CYP1A2CYP3A4 | |
| SCHEMBL5869340 | 0.83 | SLC6A4 (0.39) | SLC6A2SLC6A4PMP22CYP1A2CYP3A4 | |
| SCHEMBL5869223 | 0.83 | SLC6A2 (0.53) | SLC6A2SLC6A4CYP1A2CYP3A4CYP2D6 | |
| Oxalic Acid SCHEMBL5869712 | 0.81 | SLC6A2 (0.48) | SLC6A2SLC6A4PMP22CYP2D6SLC6A3 | |
| Oxalic Acid SCHEMBL5869404 | 0.81 | SLC6A2 (0.48) | SLC6A2SLC6A4PMP22CYP2D6SLC6A3 | |
| SCHEMBL5869182 | 0.79 | SLC6A4 (0.42) | SLC6A2SLC6A4PMP22CYP1A2CYP3A4 | |
| SCHEMBL5869725 | 0.79 | SLC6A4 (0.42) | SLC6A2SLC6A4PMP22CYP1A2CYP3A4 | |
| Oxalic Acid SCHEMBL6560834 | 0.78 | SLC6A2 (0.60) | SLC6A2SLC6A4PMP22CYP1A2CYP3A4 | |
| Oxalic Acid SCHEMBL5869360 | 0.78 | SLC6A2 (0.60) | SLC6A2SLC6A4PMP22CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037932-B2 | Heteroaryloxy 3-substituted propanamines as serotonin and norepinephrine reuptake inhibitors | ELI LILLY AND COMPANY (US) | 2006-05-02 | — | — | US | disclosed |
| EP-1397129-B1 | HETEROARYLOXY 3-SUBSTITUTED PROPANAMINES S SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITORS | LILLY CO ELI (US) | 2005-11-16 | — | — | EP | disclosed |
| US-20040176435-A1 | Heteroaryloxy 3-substituted propanamines s serotonin and norepinephrine reuptake inhibitors | ELI LILLY AND COMPANY | 2004-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176435-A1 | Heteroaryloxy 3-substituted propanamines s serotonin and norepinephrine reuptake inhibitors | ADRA2C, ADRB1, TPH1 | SLC6A2 5/4885SLC6A4 7/4885PMP22 3170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.