Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 10/20 | 0.46 |
| ▸ | NOS2 | P35228 | 10/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5869236 | 1.00 | SLC6A4 (0.46) | SLC6A4NOS2CYP2D6SLC6A2FFAR1 | |
| SCHEMBL5869247 | 0.89 | SLC6A4 (0.45) | SLC6A4NOS2CYP2D6SLC6A2SLC7A5 | |
| SCHEMBL5869352 | 0.89 | SLC6A4 (0.45) | SLC6A4NOS2CYP2D6SLC6A2SLC7A5 | |
| Hydrochloric Acid SCHEMBL5869232 | 0.85 | SLC6A4 (0.64) | SLC6A4NOS2CYP2D6SLC6A2KCNH2 | |
| Hydrochloric Acid SCHEMBL5869560 | 0.85 | SLC6A4 (0.64) | SLC6A4NOS2CYP2D6SLC6A2KCNH2 | |
| SCHEMBL5869196 | 0.83 | SLC6A4 (0.44) | SLC6A4NOS2CYP2D6SLC6A2SLC7A5 | |
| SCHEMBL5869298 | 0.83 | SLC6A4 (0.44) | SLC6A4NOS2CYP2D6SLC6A2SLC7A5 | |
| SCHEMBL5869266 | 0.79 | SLC6A4 (0.44) | SLC6A4NOS2CYP2D6SLC6A2FFAR1 | |
| SCHEMBL5869150 | 0.79 | SLC6A4 (0.44) | SLC6A4NOS2CYP2D6SLC6A2FFAR1 | |
| SCHEMBL5869305 | 0.77 | SLC6A4 (0.44) | SLC6A4NOS2CYP2D6SLC6A2SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037932-B2 | Heteroaryloxy 3-substituted propanamines as serotonin and norepinephrine reuptake inhibitors | ELI LILLY AND COMPANY (US) | 2006-05-02 | — | — | US | disclosed |
| EP-1397129-B1 | HETEROARYLOXY 3-SUBSTITUTED PROPANAMINES S SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITORS | LILLY CO ELI (US) | 2005-11-16 | — | — | EP | disclosed |
| US-20040176435-A1 | Heteroaryloxy 3-substituted propanamines s serotonin and norepinephrine reuptake inhibitors | ELI LILLY AND COMPANY | 2004-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176435-A1 | Heteroaryloxy 3-substituted propanamines s serotonin and norepinephrine reuptake inhibitors | ADRA2C, ADRB1, TPH1 | SLC6A4 7/4885NOS2 1895/4885CYP2D6 92/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.