Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 12/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | KLF10 | Q13118 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5869247 | 1.00 | SLC6A4 (0.45) | SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4 | |
| SCHEMBL5869298 | 0.94 | SLC6A4 (0.44) | SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4 | |
| SCHEMBL5869196 | 0.94 | SLC6A4 (0.44) | SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4 | |
| SCHEMBL5869236 | 0.89 | SLC6A4 (0.46) | SLC6A4SLC6A2CYP2D6KCNH2NOS2 | |
| SCHEMBL5869322 | 0.89 | SLC6A4 (0.46) | SLC6A4SLC6A2CYP2D6KCNH2NOS2 | |
| Hydrochloric Acid SCHEMBL5869276 | 0.85 | SLC6A2 (0.59) | SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL5869241 | 0.85 | SLC6A2 (0.59) | SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL5869248 | 0.80 | SLC6A2 (0.58) | SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL5869301 | 0.80 | SLC6A2 (0.58) | SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4 | |
| SCHEMBL5869266 | 0.78 | SLC6A4 (0.44) | SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037932-B2 | Heteroaryloxy 3-substituted propanamines as serotonin and norepinephrine reuptake inhibitors | ELI LILLY AND COMPANY (US) | 2006-05-02 | — | — | US | disclosed |
| EP-1397129-B1 | HETEROARYLOXY 3-SUBSTITUTED PROPANAMINES S SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITORS | LILLY CO ELI (US) | 2005-11-16 | — | — | EP | disclosed |
| US-20040176435-A1 | Heteroaryloxy 3-substituted propanamines s serotonin and norepinephrine reuptake inhibitors | ELI LILLY AND COMPANY | 2004-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176435-A1 | Heteroaryloxy 3-substituted propanamines s serotonin and norepinephrine reuptake inhibitors | ADRA2C, ADRB1, TPH1 | SLC6A4 7/4885SLC6A2 5/4885CYP2D6 92/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.