Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HEXD | Q8WVB3 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL587030 | 1.00 | HEXD (1.00) | HEXDALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL2682089 | 1.00 | HEXD (1.00) | HEXDALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL14643619 | 0.92 | HEXD (0.85) | HEXDALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL586692 | 0.91 | HEXD (0.83) | HEXDALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL14644817 | 0.90 | HEXD (0.81) | HEXDALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL14644495 | 0.90 | HEXD (0.81) | HEXDALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL14643410 | 0.90 | HEXD (0.81) | HEXDALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL587230 | 0.88 | HEXD (0.79) | HEXDALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL14643409 | 0.88 | HEXD (0.78) | HEXDALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL14643408 | 0.86 | HEXD (0.75) | HEXDALDH1A1LMNAHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2731608-B1 | INHIBITORS OF BACTERIAL TYPE III SECRETION SYSTEM | MICROBIOTIX INC (US) | 2018-03-14 | — | — | EP | disclosed |
| US-9340551-B2 | Inhibitors of bacterial type III secretion system | MICROBIOTIX, INC. (US) | 2016-05-17 | — | — | US | disclosed |
| US-9340551-B2 | Inhibitors of bacterial type III secretion system | MICROBIOTIX, INC. (US) | 2016-05-17 | — | — | US | disclosed |
| US-8906945-B2 | Inhibitors of bacterial type III secretion system | MICROBIOTIX, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-8906945-B2 | Inhibitors of bacterial type III secretion system | MICROBIOTIX, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-8906945-B2 | Inhibitors of bacterial type III secretion system | MICROBIOTIX, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-20140219995-A1 | INHIBITORS OF BACTERIAL TYPE III SECRETION SYSTEM | MICROBIOTIX, INC. (US) | 2014-08-07 | — | — | US | disclosed |
| US-20140219995-A1 | INHIBITORS OF BACTERIAL TYPE III SECRETION SYSTEM | MICROBIOTIX, INC. (US) | 2014-08-07 | — | — | US | disclosed |
| US-20140142134-A1 | INHIBITORS OF BACTERIAL TYPE III SECRETION SYSTEM | MICROBIOTIX, INC. (US) | 2014-05-22 | — | — | US | disclosed |
| US-20140142134-A1 | INHIBITORS OF BACTERIAL TYPE III SECRETION SYSTEM | MICROBIOTIX, INC. (US) | 2014-05-22 | — | — | US | disclosed |
| WO-2013010089-A2 | INHIBITORS OF BACTERIAL TYPE III SECRETION SYSTEM | MICROBIOTIX, INC. (US) | 2013-01-17 | — | — | WO | disclosed |
| WO-2013010082-A2 | INHIBITORS OF BACTERIAL TYPE III SECRETION SYSTEM | MICROBIOTIX, INC. (US) | 2013-01-17 | — | — | WO | disclosed |
| US-20120114633-A1 | Inhibitors Of Bacterial Type III Secretion System | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-05-10 | — | — | US | disclosed |
| US-20120114633-A1 | Inhibitors Of Bacterial Type III Secretion System | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-05-10 | — | — | US | disclosed |
| US-20120114633-A1 | Inhibitors Of Bacterial Type III Secretion System | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-05-10 | — | — | US | disclosed |
| EP-2416661-A1 | INHIBITORS OF BACTERIAL TYPE III SECRETION SYSTEM | Microbiotix, Inc. (US) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010118046-A1 | INHIBITORS OF BACTERIAL TYPE III SECRETION SYSTEM | MICROBIOTIX, INC. (US) | 2010-10-14 | — | — | WO | disclosed |
| WO-2010118046-A1 | INHIBITORS OF BACTERIAL TYPE III SECRETION SYSTEM | MICROBIOTIX, INC. (US) | 2010-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142134-A1 | INHIBITORS OF BACTERIAL TYPE III SECRETION SYSTEM | TNPO3, TFPI, CLPP | HEXD 642/4885ALDH1A1 4855/4885LMNA 3162/4885 |
| US-20120114633-A1 | Inhibitors Of Bacterial Type III Secretion System | CLPP, TFPI, SI | HEXD 838/4885ALDH1A1 4734/4885LMNA 4556/4885 |
| US-20140219995-A1 | INHIBITORS OF BACTERIAL TYPE III SECRETION SYSTEM | CLPP, TFPI, SI | HEXD 838/4885ALDH1A1 4734/4885LMNA 4556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.