Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HEXD | Q8WVB3 | 1/20 | 0.79 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 7/20 | 0.57 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14644817 | 0.89 | HEXD (0.81) | HEXDTSHRHPGDALDH1A1HTT | |
| SCHEMBL2682089 | 0.88 | HEXD (1.00) | HEXDTSHRHPGDALDH1A1HTT | |
| SCHEMBL587030 | 0.88 | HEXD (1.00) | HEXDTSHRHPGDALDH1A1HTT | |
| SCHEMBL587029 | 0.88 | HEXD (1.00) | HEXDTSHRHPGDALDH1A1HTT | |
| SCHEMBL10054203 | 0.88 | HEXD (0.68) | HEXDTSHRHPGDALDH1A1MAPK1 | |
| SCHEMBL10053801 | 0.87 | HEXD (0.67) | HEXDTSHRHPGDALDH1A1MAPK1 | |
| SCHEMBL14644495 | 0.87 | HEXD (0.81) | HEXDTSHRHPGDALDH2ALDH1A1 | |
| SCHEMBL10053699 | 0.84 | HEXD (0.66) | HEXDTSHRHPGDALDH1A1MAPK1 | |
| SCHEMBL586692 | 0.83 | HEXD (0.83) | HEXDTSHRHPGDALDH1A1HTT | |
| SCHEMBL10053818 | 0.82 | HEXD (0.62) | HEXDTSHRHPGDALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8906945-B2 | Inhibitors of bacterial type III secretion system | MICROBIOTIX, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-8906945-B2 | Inhibitors of bacterial type III secretion system | MICROBIOTIX, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-20120114633-A1 | Inhibitors Of Bacterial Type III Secretion System | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-05-10 | — | — | US | disclosed |
| US-20120114633-A1 | Inhibitors Of Bacterial Type III Secretion System | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-05-10 | — | — | US | disclosed |
| EP-2416661-A1 | INHIBITORS OF BACTERIAL TYPE III SECRETION SYSTEM | Microbiotix, Inc. (US) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010118046-A1 | INHIBITORS OF BACTERIAL TYPE III SECRETION SYSTEM | MICROBIOTIX, INC. (US) | 2010-10-14 | — | — | WO | disclosed |
| WO-2010118046-A1 | INHIBITORS OF BACTERIAL TYPE III SECRETION SYSTEM | MICROBIOTIX, INC. (US) | 2010-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120114633-A1 | Inhibitors Of Bacterial Type III Secretion System | CLPP, TFPI, SI | HEXD 838/4885TSHR 3101/4885HPGD 2656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.