Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 5/20 | 0.39 |
| ▸ | FABP5 | Q01469 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8257823 | 1.00 | ALDH1A1 (0.40) | ALDH1A1AKR1C1FABP4FABP5GAA | |
| SCHEMBL4368196 | 0.77 | CTSK (0.42) | ALDH1A1AKR1C1FABP4FABP5CTSK | |
| SCHEMBL3259889 | 0.75 | LMNA (0.51) | ALDH1A1GAAKMT2AUSP2 | |
| SCHEMBL3259891 | 0.75 | LMNA (0.51) | ALDH1A1GAAKMT2AUSP2 | |
| SCHEMBL13624184 | 0.75 | CTSL (0.42) | ALDH1A1AKR1C1FABP4FABP5CTSK | |
| SCHEMBL28370198 | 0.74 | LMNA (0.42) | ALDH1A1HDAC4KMT2ACYP2D6SRC | |
| SCHEMBL4079580 | 0.72 | LMNA (0.45) | ALDH1A1FABP4FABP5HTTSMN1; SMN2 | |
| SCHEMBL1838386 | 0.72 | ALDH1A1 (0.47) | ALDH1A1FABP4FABP5FAAH | |
| SCHEMBL1839565 | 0.72 | ALDH1A1 (0.47) | ALDH1A1FABP4FABP5FAAH | |
| SCHEMBL1838384 | 0.72 | ALDH1A1 (0.47) | ALDH1A1FABP4FABP5FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-6632830-B1 | Blood pressure related disease or disorder, cell proliferation disorder, kidney disorder, kinetensin associated disorder, inflammation associated disorder, or an allergic disorder | MILLENNIUM PHARMACEUTICALS, INC. | 2003-10-14 | — | — | US | disclosed |