Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 9/20 | 0.39 |
| ▸ | CTSK | P43235 | 4/20 | 0.37 |
| ▸ | CTSB | P07858 | 3/20 | 0.37 |
| ▸ | CTSS | P25774 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5870582 | 0.84 | MMP9 (0.41) | NAAACTSKCTSBCTSS | |
| SCHEMBL5870569 | 0.82 | NAAA (0.46) | NAAACTSKCTSBCTSS | |
| SCHEMBL5870407 | 0.82 | HDAC8 (0.41) | CTSKCTSBCTSS | |
| SCHEMBL5870248 | 0.79 | PSMB5 (0.43) | NAAACTSKCTSBCTSS | |
| SCHEMBL5870423 | 0.79 | NAAA (0.47) | NAAACTSKCTSBCTSS | |
| SCHEMBL5870540 | 0.78 | HDAC8 (0.45) | — | |
| SCHEMBL5870440 | 0.75 | OPRM1 (0.33) | CTSKCTSBCTSS | |
| SCHEMBL5870300 | 0.74 | NAAA (0.41) | NAAACTSKCTSBCTSS | |
| SCHEMBL5870406 | 0.74 | NAAA (0.41) | NAAACTSKCTSBCTSS | |
| SCHEMBL5870399 | 0.72 | PSMB5 (0.47) | CTSKCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132449-B2 | Inhibitors of cruzipain and other cysteine proteases | AMURA THERAPEUTICS LIMITED (GB) | 2006-11-07 | — | — | US | disclosed |
| US-20040127424-A1 | Inhibitors of cruzipain and other cysteine proteases | AMURA THERAPUTICS LIMITED (GB) | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127424-A1 | Inhibitors of cruzipain and other cysteine proteases | CPN1, CTRL, CPA1 | NAAA 1250/4885CTSK 58/4885CTSB 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.