Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.33 |
| ▸ | CTSK | P43235 | 3/20 | 0.33 |
| ▸ | CTSL | P07711 | 2/20 | 0.33 |
| ▸ | CTSS | P25774 | 2/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 7/20 | 0.31 |
| ▸ | PPARA | Q07869 | 6/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.31 |
| ▸ | PSAT1 | Q9Y617 | 2/20 | 0.31 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.31 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP8 | P22894 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5870424 | 0.82 | HDAC8 (0.41) | OPRM1CTSKCTSLCTSSCTSB | |
| SCHEMBL5870433 | 0.75 | NAAA (0.39) | CTSKCTSSCTSB | |
| SCHEMBL5870582 | 0.62 | MMP9 (0.41) | CTSKCTSSCTSBMMP9MMP8 | |
| SCHEMBL6383513 | 0.58 | NPC1 (0.50) | — | |
| SCHEMBL6383516 | 0.58 | NPC1 (0.50) | — | |
| Tyrosine SCHEMBL28854884 | 0.55 | SLC7A5 (0.83) | SRRPSAT1 | |
| SCHEMBL29696022 | 0.55 | SRR (0.50) | PPARGPPARASRRPSAT1MMP9 | |
| Trimethylammonium SCHEMBL5607489 | 0.54 | PPARA (0.52) | PPARGPPARAPPARDSRRPSAT1 | |
| SCHEMBL7896081 | 0.54 | TSHR (0.41) | CTSKCTSLCTSBSRRMMP8 | |
| SCHEMBL5096058 | 0.54 | IDH1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132449-B2 | Inhibitors of cruzipain and other cysteine proteases | AMURA THERAPEUTICS LIMITED (GB) | 2006-11-07 | — | — | US | disclosed |
| US-20040127424-A1 | Inhibitors of cruzipain and other cysteine proteases | AMURA THERAPUTICS LIMITED (GB) | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127424-A1 | Inhibitors of cruzipain and other cysteine proteases | CPN1, CTRL, CPA1 | OPRM1 2514/4885CTSK 58/4885CTSL 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.