Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.37 |
| ▸ | MME | P08473 | 3/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | MMP8 | P22894 | 2/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.36 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.36 |
| ▸ | CPA1 | P15085 | 2/20 | 0.36 |
| ▸ | CPB1 | P15086 | 1/20 | 0.36 |
| ▸ | CPA3 | P15088 | 1/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5870355 | 0.81 | ANPEP (0.42) | MMP2MMEMMP9MMP8ANPEP | |
| SCHEMBL5870283 | 0.81 | ANPEP (0.42) | MMP2MMEMMP9MMP8ANPEP | |
| SCHEMBL5096058 | 0.69 | IDH1 (0.44) | MEN1KMT2A | |
| SCHEMBL5557763 | 0.68 | MMP8 (0.64) | MMP2MMP9MMP8ANPEPMMP1 | |
| SCHEMBL5870352 | 0.66 | NTSR1 (0.40) | MMEMMP1CYP17A1CPA1ACE | |
| Biphenyl SCHEMBL5907627 | 0.65 | MMP12 (0.53) | MMP2MMP9FFAR1ADAMTS4 | |
| Biphenyl SCHEMBL27757756 | 0.65 | CPA1 (0.56) | MMP2MMEMMP9FFAR1MEN1 | |
| SCHEMBL7355706 | 0.64 | HSD17B10 (0.52) | CPA1CPB1CPA3CPB2 | |
| SCHEMBL8048833 | 0.64 | HSD17B10 (0.52) | CPA1CPB1CPA3CPB2 | |
| SCHEMBL8481077 | 0.64 | FFAR1 (0.48) | MMP2MMP9FFAR1ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132449-B2 | Inhibitors of cruzipain and other cysteine proteases | AMURA THERAPEUTICS LIMITED (GB) | 2006-11-07 | — | — | US | disclosed |