Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | RPLP1 | P05386 | 2/20 | 0.35 |
| ▸ | RPLP0 | P05388 | 2/20 | 0.35 |
| ▸ | RPS17 | P08708 | 2/20 | 0.35 |
| ▸ | RPSA | P08865 | 2/20 | 0.35 |
| ▸ | RPS2 | P15880 | 2/20 | 0.35 |
| ▸ | RPL35A | P18077 | 2/20 | 0.35 |
| ▸ | RPL7 | P18124 | 2/20 | 0.35 |
| ▸ | RPL17 | P18621 | 2/20 | 0.35 |
| ▸ | RPS4Y1 | P22090 | 2/20 | 0.35 |
| ▸ | RPS3 | P23396 | 2/20 | 0.35 |
| ▸ | RPS12 | P25398 | 2/20 | 0.35 |
| ▸ | RPL13 | P26373 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5871013 | 0.82 | KMT2A (0.40) | SLC6A2SLC6A4SLC6A3KMT2AKCNH2 | |
| SCHEMBL3278539 | 0.80 | TRPM8 (0.46) | ALDH1A1LMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13400173 | 0.80 | TRPM8 (0.46) | ALDH1A1LMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3273608 | 0.80 | TRPM8 (0.46) | ALDH1A1LMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5870950 | 0.75 | OPRD1 (0.41) | SLC6A2SLC6A4SLC6A3KMT2AKCNH2 | |
| SCHEMBL5870905 | 0.75 | CHRM1 (0.41) | KDM4EPOLBALDH1A1LMNA | |
| SCHEMBL5870807 | 0.75 | OPRD1 (0.38) | SLC6A2SLC6A4KMT2ACPN1CPB2 | |
| SCHEMBL5871051 | 0.74 | OPRD1 (0.43) | SLC6A2SLC6A4SLC6A3KMT2ACPN1 | |
| SCHEMBL7503837 | 0.73 | OPRD1 (0.44) | SLC6A2SLC6A4SLC6A3KMT2AKCNH2 | |
| SCHEMBL5871033 | 0.73 | OPRD1 (0.44) | SLC6A2SLC6A4SLC6A3KMT2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7129228-B2 | Heterocyclic analgesic compounds and methods of use thereof | SEPRACOR INC. (US) | 2006-10-31 | — | — | US | disclosed |
| US-20040209846-A1 | Heterocyclic analgesic compounds and methods of use thereof | CUNY GREGORY D (US) | 2004-10-21 | — | — | US | disclosed |
| US-6677332-B1 | AMIDE-SUBSTITUTED PIPERIDINE OR AZEPINE DERIVATIVES TO TREAT DRUG ABUSE AND TINNITUS | SEPRACOR, INC. | 2004-01-13 | — | — | US | disclosed |
| US-6645980-B1 | Ligands for biological receptors such as opiate receptors or G-protein coupled receptors used for treating pain, drug dependence or tinnitus in mammals | SEPRACOR INC. | 2003-11-11 | — | — | US | disclosed |
| US-6635661-B2 | Piperidinyl amide compounds | SEPRACOR INC. | 2003-10-21 | — | — | US | disclosed |
| WO-2002069895-A2 | HETEROCYCLIC ANALGESIC COMPOUNDS AND METHODS OF USE THEREOF | SEPRACOR, INC. (US) | 2002-09-12 | — | — | WO | disclosed |
| US-20020016337-A1 | Heterocyclic analgesic compounds and methods of use thereof | SEPRACOR INC. | 2002-02-07 | — | — | US | disclosed |
| WO-2001092226-A1 | HETEROCYCLIC ANALGESIC COMPOUNDS AND METHOD OF USE THEREOF | SEPRACOR, INC. (US) | 2001-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040209846-A1 | Heterocyclic analgesic compounds and methods of use thereof | OPRL1, TRPV1, OPRK1 | KDM4E 4237/4885POLB 4835/4885USP2 3980/4885 |
| US-20020016337-A1 | Heterocyclic analgesic compounds and methods of use thereof | OPRL1, TRPV1, OPRK1 | KDM4E 4237/4885POLB 4835/4885USP2 3980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.