Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.41 |
| ▸ | CPN1 | P15169 | 1/20 | 0.41 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.41 |
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13400173 | 1.00 | TRPM8 (0.46) | TRPM8KMT2ASLC6A2SLC6A4CPN1 | |
| SCHEMBL3278539 | 1.00 | TRPM8 (0.46) | TRPM8KMT2ASLC6A2SLC6A4CPN1 | |
| SCHEMBL5870950 | 0.85 | OPRD1 (0.41) | KMT2ASLC6A2SLC6A4CPN1CPB2 | |
| SCHEMBL5870807 | 0.84 | OPRD1 (0.38) | TRPM8KMT2ASLC6A2SLC6A4CPN1 | |
| SCHEMBL5871051 | 0.84 | OPRD1 (0.43) | TRPM8KMT2ASLC6A2SLC6A4CPN1 | |
| SCHEMBL7498243 | 0.83 | OPRD1 (0.44) | KMT2ASLC6A2SLC6A4GHSRSLC6A3 | |
| SCHEMBL5871033 | 0.83 | OPRD1 (0.44) | KMT2ASLC6A2SLC6A4GHSRSLC6A3 | |
| SCHEMBL5871013 | 0.83 | KMT2A (0.40) | KMT2ASLC6A2SLC6A4CPN1CPB2 | |
| SCHEMBL7503837 | 0.83 | OPRD1 (0.44) | KMT2ASLC6A2SLC6A4GHSRSLC6A3 | |
| SCHEMBL7493957 | 0.81 | KMT2A (0.36) | KMT2ASLC6A2SLC6A4CPN1CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7692019-B2 | Methods for the stereoselective synthesis of substituted piperidines | SEPRACOR INC. (US) | 2010-04-06 | — | — | US | disclosed |
| US-7692019-B2 | Methods for the stereoselective synthesis of substituted piperidines | SEPRACOR INC. (US) | 2010-04-06 | — | — | US | disclosed |
| US-7692019-B2 | Methods for the stereoselective synthesis of substituted piperidines | SEPRACOR INC. (US) | 2010-04-06 | — | — | US | disclosed |
| US-20060211864-A1 | Methods for the stereoselective synthesis of substituted piperidines | AQUILA BRIAN M | 2006-09-21 | — | — | US | disclosed |
| US-7005524-B2 | Methods for the stereoselective synthesis of substituted piperidines | SEPRACOR INC. (US) | 2006-02-28 | — | — | US | disclosed |
| US-20040235893-A1 | Methods for the stereoselective synthesis of substituted piperidines | AQUILA BRIAN M (US) | 2004-11-25 | — | — | US | disclosed |
| US-6703508-B2 | ANALGESICS | SEPRACOR, INC. | 2004-03-09 | — | — | US | disclosed |
| US-20020177721-A1 | Methods for the stereoselective synthesis of substituted piperidines | SEPRACOR INC. | 2002-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235893-A1 | Methods for the stereoselective synthesis of substituted piperidines | OPRK1, OPRL1, HTR5A | TRPM8 3105/4885KMT2A 1474/4885SLC6A2 218/4885 |
| US-20060211864-A1 | Methods for the stereoselective synthesis of substituted piperidines | OPRK1, OPRL1, HTR5A | TRPM8 3105/4885KMT2A 1474/4885SLC6A2 218/4885 |
| US-20020177721-A1 | Methods for the stereoselective synthesis of substituted piperidines | OPRK1, OPRL1, HTR5A | TRPM8 3105/4885KMT2A 1474/4885SLC6A2 218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.