Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | HTR1B | P28222 | 1/20 | 0.51 |
| ▸ | HTR1F | P30939 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | HTR2C | P28335 | 3/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5871355 | 0.94 | HTR1A (0.49) | HTR1AHTR1DHTR1BHTR1FHTR2A | |
| SCHEMBL5871577 | 0.94 | HTR1A (0.48) | HTR1AHTR1DHTR1BHTR1FHTR2A | |
| SCHEMBL5871739 | 0.91 | HTR1A (0.50) | HTR1AHTR1DHTR1BHTR1FHTR2A | |
| SCHEMBL5871542 | 0.91 | CACNA1G (0.45) | HTR1AHTR1DHTR1BHTR1FHTR2A | |
| SCHEMBL5871188 | 0.91 | HTR1A (0.49) | HTR1AHTR1DHTR1BHTR1FHTR2A | |
| SCHEMBL5870987 | 0.90 | HTR1A (0.48) | HTR1AHTR1DHTR1BHTR1FHTR2A | |
| SCHEMBL5871038 | 0.90 | HTR2A (0.44) | HTR1AHTR1DHTR1BHTR1FHTR2A | |
| SCHEMBL5871268 | 0.90 | HTR1A (0.45) | HTR1AHTR1DHTR1BHTR1FHTR2A | |
| SCHEMBL5871264 | 0.90 | HTR1A (0.48) | HTR1AHTR1DHTR1BHTR1FHTR2A | |
| SCHEMBL5871155 | 0.90 | ERCC1 (0.50) | HTR1AHTR1DHTR1BHTR1FHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1148188-C | Analgesics | 卫材株式会社 | 2004-05-05 | — | — | CN | claimed |
| US-6579881-B2 | Indoles | EISAI CO., LTD. (JP) | 2003-06-17 | — | — | US | claimed |
| US-20020019531-A1 | Indoles | EISAI CO., LTD. | 2002-02-14 | — | — | US | claimed |
| CN-1324239-A | Analgesics | EISAI CO LTD (JP) | 2001-11-28 | — | — | CN | claimed |
| EP-1123702-A1 | ANALGESICS | Eisai Co., Ltd. (JP) | 2001-08-16 | — | — | EP | claimed |
| EP-0976732-A1 | 1,4-SUBSTITUTED CYCLIC AMINE DERIVATIVES | Eisai Co., Ltd. (JP) | 2000-02-02 | — | — | EP | claimed |
| US-7541371-B2 | Method for treating a motor neuron disease | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-02 | — | — | US | disclosed |
| US-7541371-B2 | Method for treating a motor neuron disease | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-02 | — | — | US | disclosed |
| US-20080027039-A1 | Method for treating a motor neuron disease | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-01-31 | — | — | US | disclosed |
| US-20080027039-A1 | Method for treating a motor neuron disease | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-01-31 | — | — | US | disclosed |
| US-7071201-B2 | Serotonin antagonism; muscle relaxant for myotonia; such as 1-(1-(2-(4-methoxyphenyl)ethyl)piperidin-4-yl)-7-methoxy-1,2,3,4 -tetrahydroquinoline | EISAI CO., LTD. (JP) | 2006-07-04 | — | — | US | disclosed |
| CN-1204121-C | 1,4-substituted cyclic amine derivatives | EISAI CO LTD (JP) | 2005-06-01 | — | — | CN | disclosed |
| EP-0976732-B1 | 1,4-SUBSTITUTED CYCLIC AMINE DERIVATIVES | EISAI CO LTD (JP) | 2004-11-24 | — | — | EP | disclosed |
| US-6448243-B1 | SEROTONIN ANTAGONIST FOR TREATING, AMELIORATING AND PREVENTING SPASTIC PARALYSIS OR CENTRAL MUSCLE RELAXANTS FOR AMELIORATING MYOTONIA | EISAI CO., LTD. (JP) | 2002-09-10 | — | — | US | disclosed |
| US-20020086999-A1 | Certain quinoline derivatives | EISAI CO., LTD. | 2002-07-04 | — | — | US | disclosed |
| US-20020019531-A1 | Indoles | EISAI CO., LTD. | 2002-02-14 | — | — | US | disclosed |
| CN-1324239-A | Analgesics | EISAI CO LTD (JP) | 2001-11-28 | — | — | CN | disclosed |
| EP-1123702-A1 | ANALGESICS | Eisai Co., Ltd. (JP) | 2001-08-16 | — | — | EP | disclosed |
| CN-1253547-A | 1,4-substituted cyclic amine derivatives | EISAI CO LTD (JP) | 2000-05-17 | — | — | CN | disclosed |
| EP-0976732-A1 | 1,4-SUBSTITUTED CYCLIC AMINE DERIVATIVES | Eisai Co., Ltd. (JP) | 2000-02-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020019531-A1 | Indoles | INMT, MUSK, MB | HTR1A 17/4885HTR1D 31/4885HTR1B 84/4885 |
| US-20080027039-A1 | Method for treating a motor neuron disease | SMN1; SMN2, NLN, SLC18A2 | HTR1A 33/4885HTR1D 160/4885HTR1B 24/4885 |
| US-20020086999-A1 | Certain quinoline derivatives | CHRM1, CHRNA5, CHRNA4 | HTR1A 14/4885HTR1D 27/4885HTR1B 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.