Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.44 |
| ▸ | PDE4A | P27815 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | COMT | P21964 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1523205 | 0.92 | ALDH1A1 (0.63) | ALDH1A1KDM4EPDE4DPDE4APDE4B | |
| SCHEMBL5872072 | 0.90 | KDM4E (0.60) | ALDH1A1KDM4EPDE4DPDE4APDE4B | |
| SCHEMBL1523271 | 0.85 | RXFP1 (0.51) | ALDH1A1KDM4EFEN1MAPTMEN1 | |
| SCHEMBL5871967 | 0.80 | FEN1 (0.54) | ALDH1A1KDM4EFEN1MAPTCOMT | |
| SCHEMBL8695153 | 0.80 | HSD17B10 (0.47) | ALDH1A1KDM4EPDE4DPDE4APDE4B | |
| SCHEMBL829931 | 0.79 | MEN1 (0.63) | ALDH1A1KDM4EPDE4DPDE4APDE4B | |
| SCHEMBL17461858 | 0.78 | PDE4A (0.51) | KDM4EPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7462175 | 0.76 | ALDH1A1 (0.83) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL5871817 | 0.76 | MAPT (0.61) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL3514617 | 0.75 | FEN1 (0.47) | ALDH1A1KDM4EFEN1MAPTCOMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071187-B2 | Naphthyridine derivatives | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2006-07-04 | — | — | US | disclosed |
| US-20040214853-A1 | Naphthyridine derivatives | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2004-10-28 | — | — | US | disclosed |
| EP-1426374-A1 | NAPHTHYRIDINE DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2004-06-09 | — | — | EP | disclosed |
| EP-1172109-A1 | COMPOSITIONS FOR PREVENTING AND TREATING TYPE I ALLERGY | Sunstar Inc. (JP) | 2002-01-16 | — | — | EP | disclosed |
| EP-1172443-A1 | METHOD FOR SCREENING CYSTEINE PROTEASE INHIBITOR | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2002-01-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040214853-A1 | Naphthyridine derivatives | MT-ND1, OPRD1, NR0B1 | ALDH1A1 272/4885KDM4E 4050/4885PDE4D 1360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.