Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 3/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
| ▸ | KDM6A | O15550 | 1/20 | 0.39 |
| ▸ | TET3 | O43151 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | KDM4B | O94953 | 1/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3516135 | 0.81 | FEN1 (0.46) | FEN1DAOKDM4EHSP90AA1IDO1 | |
| SCHEMBL5871967 | 0.81 | FEN1 (0.54) | FEN1FTOKDM4ENPSR1MAPT | |
| SCHEMBL5872072 | 0.79 | KDM4E (0.60) | FEN1KDM4ENPC1RAB9ANPSR1 | |
| SCHEMBL2409501 | 0.78 | FEN1 (0.57) | FEN1MAPTKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4460861 | 0.78 | FEN1 (0.47) | FEN1DAOKMT2AALDH1A1HTT | |
| SCHEMBL18136095 | 0.78 | FEN1 (0.47) | FEN1DAOFTOKDM4EMEN1 | |
| SCHEMBL3517544 | 0.76 | FEN1 (0.42) | FEN1DAOKDM4EL3MBTL1NPC1 | |
| SCHEMBL3517754 | 0.76 | PIK3CD (0.52) | FEN1DAOMEN1KMT2A | |
| SCHEMBL5872017 | 0.75 | ALDH1A1 (0.51) | FEN1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL829931 | 0.74 | MEN1 (0.63) | KDM4EL3MBTL1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10980754-B2 | Anti-fungal compounds | SAINT LOUIS UNIVERSITY (US) | 2021-04-20 | — | — | US | disclosed |
| US-20190099385-A1 | ANTI-FUNGAL COMPOUNDS | SAINT LOUIS UNIVERSITY (US) | 2019-04-04 | — | — | US | disclosed |
| WO-2017184752-A1 | ANTI-FUNGAL COMPOUNDS | SAINT LOUIS UNIVERSITY (US) | 2017-10-26 | — | — | WO | disclosed |
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
| WO-2008010964-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK & CO., INC. (US) | 2008-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | RNASEH1, RNASE1, RNASEL | FEN1 115/4885DAO 3247/4885FTO 3677/4885 |
| US-20190099385-A1 | ANTI-FUNGAL COMPOUNDS | ERG28, NANS, DPM1 | FEN1 1355/4885DAO 1179/4885FTO 3816/4885 |
| US-10980754-B2 | Anti-fungal compounds | ERG28, NANS, DPM1 | FEN1 1355/4885DAO 1179/4885FTO 3816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.