Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 8/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9985955 | 1.00 | PPARG (0.50) | PPARGLMNANFE2L2HTTGAA | |
| SCHEMBL12513073 | 1.00 | PPARG (0.50) | PPARGLMNANFE2L2HTTGAA | |
| SCHEMBL5872237 | 0.86 | PPARG (0.46) | PPARGLMNANFE2L2HTTGAA | |
| SCHEMBL1324312 | 0.84 | PPARG (0.52) | PPARGLMNANFE2L2HTTGAA | |
| SCHEMBL1324441 | 0.84 | PPARG (0.52) | PPARGLMNANFE2L2HTTGAA | |
| SCHEMBL1324308 | 0.84 | PPARG (0.52) | PPARGLMNANFE2L2HTTGAA | |
| SCHEMBL1324315 | 0.84 | PPARG (0.52) | PPARGLMNANFE2L2HTTGAA | |
| SCHEMBL5872086 | 0.83 | LMNA (0.52) | PPARGLMNANFE2L2HTTGAA | |
| SCHEMBL5872367 | 0.81 | LMNA (0.46) | PPARGLMNANFE2L2HTTGAA | |
| SCHEMBL7902156 | 0.81 | LMNA (0.46) | PPARGLMNANFE2L2HTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6559198-B2 | A contact lens comprising a copolymer consisting essentially of from about 25 to about 60 weight percent of a ethylenically unsaturated fluorosulfone ester monomer having the general formula comonomer selected from the group consisting of | NOVICKY NICK (CA) | 2003-05-06 | — | — | US | claimed |
| US-20030027886-A1 | Fluorocarbon-sulfone hydrophilic contact lenses, optical medical devices and compositions thereof | NOVICKY NICK (CA) | 2003-02-06 | — | — | US | claimed |
| EP-0231572-B1 | Silicone-sulfone and silicone-fluorocarbon-sulfone gas permeable contact lenses and compositions thereof | PROGRESSIVE OPTICAL RES LTD (CA) | 1994-11-02 | — | — | EP | claimed |
| US-4748224-A | Silicone-sulfone and silicone-fluorocarbon-sulfone gas permeable contact lenses and compositions thereof | Devou, Maureen J. (CA) | 1988-05-31 | — | — | US | claimed |
| EP-0231572-A2 | Silicone-sulfone and silicone-fluorocarbon-sulfone gas permeable contact lenses and compositions thereof | PROGRESSIVE OPTICAL RESEARCH LTD. (CA) | 1987-08-12 | — | — | EP | claimed |
| EP-2582675-B1 | COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS | CHANGZHOU LE SUN PHARMACEUTICALS LTD (CN) | 2016-06-08 | — | — | EP | disclosed |
| CN-103068802-B | Compounds for treating proliferative disorders | LE SUN PHARMACEUTICALS LTD | 2014-12-03 | — | — | CN | disclosed |
| US-8829003-B2 | Compounds for treating proliferative disorders | CHANGZHOU LE SUN PHARMACEUTICALS LIMITED (CN) | 2014-09-09 | — | — | US | disclosed |
| US-20130190325-A1 | COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS | ITEK VENTURES PTY LTD (AU) | 2013-07-25 | — | — | US | disclosed |
| EP-2582675-A1 | COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS | Itek Ventures Pty Ltd (AU) | 2013-04-24 | — | — | EP | disclosed |
| CN-103068802-A | Compounds for treating proliferative disorders | ITEK VENTURES PTY LTD | 2013-04-24 | — | — | CN | disclosed |
| WO-2011161446-A1 | COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS | THE UNIVERSITY OF NOTTINGHAM (GB) | 2011-12-29 | — | — | WO | disclosed |
| US-20030027886-A1 | Fluorocarbon-sulfone hydrophilic contact lenses, optical medical devices and compositions thereof | NOVICKY NICK (CA) | 2003-02-06 | — | — | US | disclosed |
| EP-0231572-B1 | Silicone-sulfone and silicone-fluorocarbon-sulfone gas permeable contact lenses and compositions thereof | PROGRESSIVE OPTICAL RES LTD (CA) | 1994-11-02 | — | — | EP | disclosed |
| US-5093447-A | Contact lenses | NOVICKY NICK N (CA) | 1992-03-03 | — | — | US | disclosed |
| US-4948855-A | COPOLYMER OF UNSATURATED SILOXANYLALKOXYESTER AND VINYL SILFONE | PROGRESSIVE CHEMICAL RESEARCH, LTD. (CA) | 1990-08-14 | — | — | US | disclosed |
| US-4861850-A | CONTACT LENSES | PROGRESSIVE CHEMICAL RESEARCH, LTD. (CA) | 1989-08-29 | — | — | US | disclosed |
| US-4748224-A | Silicone-sulfone and silicone-fluorocarbon-sulfone gas permeable contact lenses and compositions thereof | Devou, Maureen J. (CA) | 1988-05-31 | — | — | US | disclosed |
| US-4743106-A | POLYMER HAVING AN ORGANOSILOXANYLALKOXY ESTER OF (METH)ACRYLIC ACID MONOMER; MACHINING | Devou, Maureen J. (CA) | 1988-05-10 | — | — | US | disclosed |
| EP-0231572-A2 | Silicone-sulfone and silicone-fluorocarbon-sulfone gas permeable contact lenses and compositions thereof | PROGRESSIVE OPTICAL RESEARCH LTD. (CA) | 1987-08-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130190325-A1 | COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS | JAK3, CDK3, PHKA1 | PPARG 1434/4885LMNA 2692/4885NFE2L2 1764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.