SCHEMBL5872319

SCHEMBL5872319

OC1(c2ccc(C(F)(F)F)cc2C(F)(F)F)c2c(F)c(F)c(F)c(F)c2-c2c(F)c(F)c(F)c(F)c21

nearest known ligand 0.39

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CES2 O00748 3/20 0.39
PDE2A O00408 2/20 0.32
PDK2 Q15119 1/20 0.32
POLQ O75417 1/20 0.31
P2RX1 P51575 1/20 0.31
MGLL Q99685 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7200037 0.72 CES2 (0.34) CES2P2RX1
SCHEMBL5872317 0.66 PNMT (0.38) CES2POLQ
SCHEMBL5872347 0.63
SCHEMBL15118588 0.63 HIF1A (0.41) CES2
SCHEMBL2699647 0.62 CES2 (0.52) CES2PDE2A
SCHEMBL30417923 0.62 CES2 (0.52) CES2PDE2A
SCHEMBL6061078 0.61 CES2 (0.56) CES2PDE2A
SCHEMBL29242797 0.61 MEN1 (0.43) CES2PDE2AP2RX1
SCHEMBL26375368 0.61 NOTUM (0.45) PDE2A
SCHEMBL11603910 0.61 CES2 (0.43) CES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1425318-B1 ACTIVATING ORGANOMETALLIC COMPOSITION FOR THE (CO)POLYMERIZATION OF ALPHA-OLEFINS COMPRISING FLUORINATED CYCLOPENTADIENYL COMPOUNDS VERSALIS SPA (IT) 2013-01-16 EP disclosed
US-7081505-B2 Activating organometallic composition for the (co) polymerization of alpha-olefins comprising fluorinated cyclopentadienyl compounds POLIMERI EUROPA S.P.A. (IT) 2006-07-25 US disclosed
US-20040198934-A1 Activating organometallic composition for the (co) polymerization of alpha-olefins comprising fluorinated cyclopentadienyl compounds POLIMERI EUROPA S.P.A. (IT) 2004-10-07 US disclosed
EP-1425318-A1 ACTIVATING ORGANOMETALLIC COMPOSITION FOR THE (CO)POLYMERIZATION OF ALPHA-OLEFINS COMPRISING FLUORINATED CYCLOPENTADIENYL COMPOUNDS Polimeri Europa S.p.A. (IT) 2004-06-09 EP disclosed
US-6596891-B1 Reaction product of fluoroorganic compound and organometallic compound ENICHEM S.P.A. (IT) 2003-07-22 US disclosed
WO-2003010210-A1 ACTIVATING ORGANOMETALLIC COMPOSITION FOR THE (CO)POLYMERIZATION OF ALPHA-OLEFINS COMPRISING FLUORINATED CYCLOPENTADIENYL COMPOUNDS POLIMERI EUROPA S.P.A. (IT) 2003-02-06 WO disclosed
EP-1013675-B1 Activating composition of metallocene complexes in the catalysis of (co)polymerization processes of olefins POLIMERI EUROPA SPA (IT) 2002-07-31 EP disclosed
EP-1013675-A2 Activating composition of metallocene complexes in the catalysis of (co)polymerization processes of olefins Enichem S.p.A. (IT) 2000-06-28 EP disclosed