Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 4/20 | 0.32 |
| ▸ | MMP3 | P08254 | 2/20 | 0.32 |
| ▸ | CASP1 | P29466 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | CCKBR | P32239 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872352 | 1.00 | GAA (0.35) | GAAHTTPAX8ATMCCR5 | |
| SCHEMBL6941289 | 0.80 | TSHR (0.34) | MMP3MMP2MMP9MEN1CYP1A2 | |
| SCHEMBL5872468 | 0.78 | HDAC8 (0.36) | GAAHTTCYP1A2POLBTSHR | |
| SCHEMBL5872462 | 0.78 | HDAC8 (0.36) | GAAHTTCYP1A2POLBTSHR | |
| SCHEMBL7780090 | 0.78 | MMP2 (0.38) | MMP3MMP2MMP9MEN1CYP1A2 | |
| SCHEMBL2077742 | 0.76 | ATM (0.35) | ATMMMP2MMP9HSD11B1CYP1A2 | |
| SCHEMBL2513974 | 0.76 | ATM (0.35) | ATMMMP2MMP9HSD11B1CYP1A2 | |
| SCHEMBL2077738 | 0.76 | ATM (0.35) | ATMMMP2MMP9HSD11B1CYP1A2 | |
| SCHEMBL5872252 | 0.75 | CYP1A2 (0.36) | GAAATMHSD11B1ELANEMEN1 | |
| SCHEMBL5872329 | 0.75 | CYP1A2 (0.36) | GAAATMHSD11B1ELANEMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2943475-B1 | PROCESS FOR THE PREPARATION OF A FLUOROLACTON DERIVATIVE | GILEAD PHARMASSET LLC (US) | 2017-10-25 | — | — | EP | disclosed |
| US-7126028-B1 | Process for preparing chiral compounds | THE UNIVERSITY COURT OF THE UNIVERSITY OF ST. ANDREWS (GB) | 2006-10-24 | — | — | US | disclosed |
| EP-1135349-A1 | PROCESS FOR PREPARING CHIRAL COMPOUNDS | UNIVERSITY OF DURHAM (GB) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000034210-A1 | PROCESS FOR PREPARING CHIRAL COMPOUNDS | UNIVERSITY OF DURHAM (GB) | 2000-06-15 | — | — | WO | disclosed |