Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | LIG1 | P18858 | 1/20 | 0.53 |
| ▸ | DAO | P14920 | 7/20 | 0.50 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2786198 | 0.85 | LMNA (0.54) | PKMLIG1DAOFBP1MEN1 | |
| SCHEMBL2785866 | 0.84 | HPGDS (0.56) | FBP1MEN1KMT2ARAB9APOLB | |
| SCHEMBL7060968 | 0.77 | PKM (0.58) | PKMLIG1DAOMEN1KMT2A | |
| SCHEMBL11392259 | 0.75 | PKM (0.56) | PKMLIG1DAOMEN1KMT2A | |
| SCHEMBL11400595 | 0.75 | PKM (0.56) | PKMLIG1DAOMEN1KMT2A | |
| SCHEMBL2786209 | 0.74 | FBP1 (0.46) | FBP1RAB9ACES2CES1 | |
| SCHEMBL2432241 | 0.74 | FBP1 (0.68) | DAOFBP1MEN1KMT2ARAB9A | |
| SCHEMBL28419126 | 0.73 | DAO (0.45) | DAOFBP1MEN1KMT2ARAB9A | |
| SCHEMBL19259788 | 0.72 | HPGD (0.42) | PKMMEN1KMT2ARAB9APOLB | |
| SCHEMBL28644408 | 0.71 | POLB (0.35) | PKMFBP1MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7084136-B2 | Drug composition antagonistic to both PGD2/TXA2 receptors | SHIONOGI & CO., LTD. (JP) | 2006-08-01 | — | — | US | disclosed |
| US-20040024019-A1 | Drug composition antagonistic to both pgd2/txa2 receptors | SHIONOGI & CO. LTD. (JP) | 2004-02-05 | — | — | US | disclosed |
| EP-1295872-A1 | DRUG COMPOSITION ANTAGONISTIC TO BOTH PGD 2?/TXA 2? RECEPTORS | SHIONOGI & CO., LTD. (JP) | 2003-03-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040024019-A1 | Drug composition antagonistic to both pgd2/txa2 receptors | PTGER1, PTGER2, TBXA2R | PKM 3883/4885LIG1 2403/4885DAO 2366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.