Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPA1 | P27694 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.38 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.38 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | COMT | P21964 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5747881 | 0.89 | KDM4E (0.45) | RPA1MCL1MAP2K4KDM4EALOX5 | |
| SCHEMBL5773483 | 0.89 | KDM4E (0.51) | MAPK1KDM4EHCRTR1HCRTR2SMN1; SMN2 | |
| SCHEMBL5773795 | 0.83 | MAP2K4 (0.53) | MAPK1MAP2K4MAPKAPK3MAPK6KDM4E | |
| SCHEMBL5873216 | 0.81 | KDM4E (0.41) | MAPK1MAP2K4MAPK6KDM4ESMN1; SMN2 | |
| SCHEMBL5872933 | 0.80 | KDM4E (0.41) | MAPK1MAP2K4KDM4EHCRTR1HCRTR2 | |
| SCHEMBL5872941 | 0.79 | CDC7 (0.44) | MAPK1KDM4E | |
| SCHEMBL5773580 | 0.78 | L3MBTL1 (0.50) | MAPK1KDM4ESMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL5873225 | 0.78 | KDM4E (0.49) | MAPK1MAP2K4KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL5775974 | 0.78 | ATAD2 (0.40) | KDM4ESMN1; SMN2LMNAALDH1A1HPGD | |
| SCHEMBL5774853 | 0.78 | TRPM8 (0.43) | MAPK1KDM4EHCRTR1HCRTR2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984652-B2 | Gyrase inhibitors | WARNER-LAMBERT COMPANY LLC (US) | 2006-01-10 | — | — | US | disclosed |
| US-20050054697-A1 | Gyrase inhibitors | PFIZER INC. | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054697-A1 | Gyrase inhibitors | TOP1, TOP2A, TOP2B | RPA1 80/4885MCL1 1826/4885MAPK1 2837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.