Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TACR3 | P29371 | 1/20 | 0.41 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | FABP6 | P51161 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | CLK3 | P49761 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872927 | 0.93 | ALDH1A1 (0.41) | ALDH1A1KDM4EMAPTTSHRMAPK1 | |
| SCHEMBL5873066 | 0.89 | MEN1 (0.42) | ALDH1A1KDM4ETACR3MEN1KMT2A | |
| SCHEMBL5873016 | 0.88 | KDM4E (0.44) | ALDH1A1KDM4EMAPTTSHRMAPK1 | |
| SCHEMBL5873133 | 0.88 | TACR3 (0.42) | ALDH1A1KDM4EMAPTTSHRMAPK1 | |
| SCHEMBL5769525 | 0.87 | PIM1 (0.41) | ALDH1A1MEN1KMT2ACLK2CLK3 | |
| SCHEMBL5873035 | 0.87 | PHGDH (0.36) | ALDH1A1KDM4EMAPTTSHRMAPK1 | |
| SCHEMBL5873193 | 0.87 | DYRK1A (0.41) | ALDH1A1KDM4EMEN1KMT2AABCB1 | |
| SCHEMBL5873067 | 0.85 | MKNK1 (0.43) | ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL5872886 | 0.85 | NAMPT (0.39) | ALDH1A1KDM4EMAPTTACR3MEN1 | |
| SCHEMBL5873155 | 0.84 | SLC6A7 (0.42) | ALDH1A1KDM4EMAPTTACR3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984652-B2 | Gyrase inhibitors | WARNER-LAMBERT COMPANY LLC (US) | 2006-01-10 | — | — | US | disclosed |
| US-20050250823-A1 | Gyrase inhibitors | YAGER KRAIG | 2005-11-10 | — | — | US | disclosed |
| US-20050054697-A1 | Gyrase inhibitors | PFIZER INC. | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054697-A1 | Gyrase inhibitors | TOP1, TOP2A, TOP2B | ALDH1A1 2272/4885KDM4E 2869/4885MAPT 3874/4885 |
| US-20050250823-A1 | Gyrase inhibitors | TOP1, TOP2A, TOP2B | ALDH1A1 2272/4885KDM4E 2869/4885MAPT 3874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.