Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.36 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 7/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.33 |
| ▸ | CLK2 | P49760 | 3/20 | 0.33 |
| ▸ | CLK3 | P49761 | 3/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | TACR3 | P29371 | 1/20 | 0.32 |
| ▸ | WNT1 | P04628 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872959 | 0.87 | ALDH1A1 (0.42) | PHGDHDYRK1ACLK2CLK3KDM4E | |
| SCHEMBL5873033 | 0.82 | DYRK1A (0.34) | PHGDHPIM1DYRK1ACLK2CLK3 | |
| SCHEMBL5872927 | 0.80 | ALDH1A1 (0.41) | DYRK1ACLK2CLK3SRPK1KDM4E | |
| SCHEMBL5873066 | 0.75 | MEN1 (0.42) | DYRK1ACLK2CLK3KDM4EALDH1A1 | |
| SCHEMBL5873016 | 0.75 | KDM4E (0.44) | KDM4EALDH1A1MAPTTSHRMAPK1 | |
| SCHEMBL5873133 | 0.74 | TACR3 (0.42) | DYRK1ACLK2CLK3KDM4EALDH1A1 | |
| SCHEMBL5873193 | 0.73 | DYRK1A (0.41) | MAP2K4PIM1DYRK1ACLK2CLK3 | |
| SCHEMBL5873067 | 0.73 | MKNK1 (0.43) | MAP2K4PIM1KDM4EALDH1A1 | |
| SCHEMBL5769525 | 0.73 | PIM1 (0.41) | MAP2K4PIM1DYRK1ACLK2CLK3 | |
| SCHEMBL5873064 | 0.72 | WNT1 (0.38) | MAP2K4PIM1DYRK1ACLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984652-B2 | Gyrase inhibitors | WARNER-LAMBERT COMPANY LLC (US) | 2006-01-10 | — | — | US | disclosed |
| US-20050054697-A1 | Gyrase inhibitors | PFIZER INC. | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054697-A1 | Gyrase inhibitors | TOP1, TOP2A, TOP2B | PHGDH 408/4885MAP2K4 2844/4885PIM1 1909/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.