Known targets — ChEMBL curated mechanism
BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | TSHR | P16473 | 3/20 | 0.67 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethylamine SCHEMBL27879398 | 0.89 | SMN1; SMN2 (0.53) | SMN1; SMN2TSHRPSIP1LMNAKDM4E | |
| Propane SCHEMBL28882618 | 0.87 | TSHR (0.80) | SMN1; SMN2TSHRPSIP1LMNAKDM4E | |
| SCHEMBL6736149 | 0.85 | SMN1; SMN2 (0.70) | SMN1; SMN2TSHRPSIP1LMNAKDM4E | |
| SCHEMBL27464245 | 0.85 | TSHR (0.76) | SMN1; SMN2TSHRPSIP1LMNAKDM4E | |
| SCHEMBL3719208 | 0.85 | TSHR (0.76) | SMN1; SMN2TSHRPSIP1LMNAKDM4E | |
| Alcohol SCHEMBL281881 | 0.85 | TSHR (0.76) | SMN1; SMN2TSHRPSIP1LMNAKDM4E | |
| Butane SCHEMBL2906063 | 0.85 | TSHR (0.76) | SMN1; SMN2TSHRPSIP1LMNAKDM4E | |
| SCHEMBL2638204 | 0.84 | TSHR (0.84) | SMN1; SMN2TSHRPSIP1LMNAKDM4E | |
| SCHEMBL6904987 | 0.84 | SMN1; SMN2 (0.61) | SMN1; SMN2TSHRPSIP1LMNAKDM4E | |
| Ethylamine SCHEMBL5875345 | 0.83 | TSHR (0.73) | SMN1; SMN2TSHRPSIP1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119430811-A | Reinforced modified granite powder-based road base material and preparation method thereof | 中冶武汉冶金建筑研究院有限公司 | 2025-02-14 | — | — | CN | claimed |
| CN-119430811-A | Reinforced modified granite powder-based road base material and preparation method thereof | 中冶武汉冶金建筑研究院有限公司 | 2025-02-14 | — | — | CN | disclosed |
| CN-112513016-B | Sulfur-containing polymerizable monomer and use thereof | 尚美德齿科材料有限公司 | 2023-12-19 | — | — | CN | disclosed |
| CN-112940432-B | Polymerizable monomer for dental material, composition, adhesive dental material, and kit | 三井化学株式会社 | 2022-12-30 | — | — | CN | disclosed |
| CN-107427414-B | Polymerizable monomer for dental material, composition, adhesive dental material, and kit | 三井化学株式会社 | 2021-07-02 | — | — | CN | disclosed |
| CN-112940432-A | Polymerizable monomer for dental material, composition, adhesive dental material, and kit | 三井化学株式会社 | 2021-06-11 | — | — | CN | disclosed |
| CN-112513016-A | Sulfur-containing polymerizable monomer and use thereof | 尚美德齿科材料有限公司 | 2021-03-16 | — | — | CN | disclosed |
| CN-106535815-B | Reactive micro-applicator with metal-containing additives for applying dental adhesives | 古莎有限公司 | 2020-05-29 | — | — | CN | disclosed |
| CN-101752098-B | Method of manufacturing solid electrolytic capacitor | SANYO ELECTRIC CO | 2012-11-14 | — | — | CN | disclosed |
| CN-101752098-A | Method of manufacturing solid electrolytic capacitor | SANYO ELECTRIC CO | 2010-06-23 | — | — | CN | disclosed |
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| EP-0736574-B1 | Thermoplastic resin composition comprising carbonate and acrylic resin | GEN ELECTRIC (US) | 2004-06-02 | — | — | EP | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |
| US-6103827-A | A TRANSPARENT THERMOPLASTIC RESIN BLENDS | GENERAL ELECTRIC COMPANY (US) | 2000-08-15 | — | — | US | disclosed |
| US-5883194-A | RADIATION TRANSPARENT THERMOPLASTIC RESINS OF CARBONATE AND ESTER BLENDS WITH ACRYLATE RESINS AND CATALYSTS | GENERAL ELECTRIC COMPANY (US) | 1999-03-16 | — | — | US | disclosed |
| CN-1141935-A | Thermoplastic resin composition | GEN ELECTRICS CORP (US) | 1997-02-05 | — | — | CN | disclosed |
| EP-0736574-A2 | Thermoplastic resin composition comprising carbonate and acrylic resin | GENERAL ELECTRIC COMPANY (US) | 1996-10-09 | — | — | EP | disclosed |