Known targets — ChEMBL curated mechanism
BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.46 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butane SCHEMBL2906063 | 0.86 | TSHR (0.76) | SMN1; SMN2TSHRPSIP1CA1CA2 | |
| Diethylamine SCHEMBL5874415 | 0.84 | SMN1; SMN2 (0.67) | SMN1; SMN2TSHRPSIP1CA1CA2 | |
| Propane SCHEMBL28882618 | 0.83 | TSHR (0.80) | SMN1; SMN2TSHRPSIP1CA1CA2 | |
| SCHEMBL8009507 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2TSHRDRD2DRD4DRD3 | |
| SCHEMBL6667980 | 0.83 | CA2 (0.50) | SMN1; SMN2TSHRCA1CA2MMP1 | |
| Diethanolamine SCHEMBL5874579 | 0.82 | SMN1; SMN2 (0.64) | SMN1; SMN2TSHRCA1CA2MMP1 | |
| Hexane SCHEMBL27501792 | 0.82 | TSHR (0.70) | SMN1; SMN2TSHRPSIP1MMP1MMP13 | |
| Propanol SCHEMBL28732212 | 0.82 | TSHR (0.70) | SMN1; SMN2TSHRPSIP1CA1CA2 | |
| SCHEMBL6736149 | 0.82 | SMN1; SMN2 (0.70) | SMN1; SMN2TSHRPSIP1CA1CA2 | |
| Alcohol SCHEMBL281881 | 0.81 | TSHR (0.76) | SMN1; SMN2TSHRPSIP1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0736574-B1 | Thermoplastic resin composition comprising carbonate and acrylic resin | GEN ELECTRIC (US) | 2004-06-02 | — | — | EP | disclosed |
| US-6103827-A | A TRANSPARENT THERMOPLASTIC RESIN BLENDS | GENERAL ELECTRIC COMPANY (US) | 2000-08-15 | — | — | US | disclosed |
| US-5883194-A | RADIATION TRANSPARENT THERMOPLASTIC RESINS OF CARBONATE AND ESTER BLENDS WITH ACRYLATE RESINS AND CATALYSTS | GENERAL ELECTRIC COMPANY (US) | 1999-03-16 | — | — | US | disclosed |
| CN-1141935-A | Thermoplastic resin composition | GEN ELECTRICS CORP (US) | 1997-02-05 | — | — | CN | disclosed |
| EP-0736574-A2 | Thermoplastic resin composition comprising carbonate and acrylic resin | GENERAL ELECTRIC COMPANY (US) | 1996-10-09 | — | — | EP | disclosed |