Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.40 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL5179301 | 0.94 | ALDH1A1 (0.44) | KMT2AGABRA1GABRB2MAPTHPGD | |
| Oxalic Acid SCHEMBL153610 | 0.94 | ALDH1A1 (0.44) | KMT2AGABRA1GABRB2MAPTHPGD | |
| Acetic Acid SCHEMBL1047016 | 0.94 | HPGD (0.40) | KMT2AGABRA1GABRB2MAPTHPGD | |
| Methyl Alcohol SCHEMBL6949733 | 0.89 | GABRA1 (0.45) | KMT2AGABRA1GABRB2CASRGAA | |
| SCHEMBL164361 | 0.89 | TSHR (0.45) | GABRA1GABRB2CASRALDH1A1ATM | |
| SCHEMBL29581427 | 0.89 | TSHR (0.45) | GABRA1GABRB2CASRALDH1A1ATM | |
| Trichloroacetic Acid SCHEMBL5874544 | 0.89 | KMT2A (0.39) | KMT2AGABRA1GABRB2MAPTHPGD | |
| Trifluoroacetic Acid SCHEMBL5874682 | 0.89 | KDM4E (0.41) | KMT2AGABRA1GABRB2MAPTHPGD | |
| SCHEMBL10640465 | 0.89 | KCNN4 (0.39) | KMT2AGABRA1GABRB2MAPTHPGD | |
| Malonic Acid SCHEMBL5874902 | 0.89 | GAA (0.41) | KMT2AGABRA1GABRB2MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |