Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Quinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MGAM | O43451 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL11274861 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNARAB9ACYP3A4 | |
| Quinoline SCHEMBL7884120 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNARAB9ACYP3A4 | |
| Quinoline SCHEMBL27293512 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNARAB9ACYP3A4 | |
| Quinoline SCHEMBL27800002 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNARAB9ACYP3A4 | |
| Quinoline SCHEMBL7886400 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNARAB9ACYP3A4 | |
| Quinoline SCHEMBL5874264 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNARAB9ACYP3A4 | |
| Quinoline SCHEMBL7886403 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNARAB9ACYP3A4 | |
| Quinoline SCHEMBL5874270 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNARAB9ACYP3A4 | |
| Quinoline SCHEMBL5874253 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNARAB9ACYP3A4 | |
| Quinoline SCHEMBL28116721 | 0.93 | ALDH1A1 (0.57) | ALDH1A1KDM4ELMNARAB9ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |