Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Quinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MGAM | O43451 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL11274861 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNARAB9ACYP3A4 | |
| Quinoline SCHEMBL7884120 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNARAB9ACYP3A4 | |
| Quinoline SCHEMBL27293512 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNARAB9ACYP3A4 | |
| Quinoline SCHEMBL27800002 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNARAB9ACYP3A4 | |
| Quinoline SCHEMBL7886400 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNARAB9ACYP3A4 | |
| Quinoline SCHEMBL7886403 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNARAB9ACYP3A4 | |
| Quinoline SCHEMBL5874270 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNARAB9ACYP3A4 | |
| Quinoline SCHEMBL5874253 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNARAB9ACYP3A4 | |
| Quinoline SCHEMBL5874841 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNARAB9ACYP3A4 | |
| Quinoline SCHEMBL28116721 | 0.93 | ALDH1A1 (0.57) | ALDH1A1KDM4ELMNARAB9ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104903321-B | Three ring benzimidazoles are substituted as kinase inhibitor | 赛尔维他股份公司 | 2017-10-24 | — | — | CN | claimed |
| CN-105377826-A | Process for producing heterocyclic compound | NISSAN CHEMICAL IND LTD | 2016-03-02 | — | — | CN | claimed |
| CN-104903321-A | Substituted tricyclic benzimidazoles as kinase inhibitors | SELVITA S A | 2015-09-09 | — | — | CN | claimed |
| CN-121703302-A | Method for determining Bedaquinoline fumarate cleaning verification target residues | 陕西汉江药业集团股份有限公司 | 2026-03-20 | — | — | CN | disclosed |
| CN-120992801-A | Method for detecting maleic acid residues in bedaquiline fumarate | 陕西汉江药业集团股份有限公司 | 2025-11-21 | — | — | CN | disclosed |
| CN-118150734-A | Method for detecting optical isomer in bedaquiline fumarate | 浙江海正药业股份有限公司 | 2024-06-07 | — | — | CN | disclosed |
| CN-118150734-A | Method for detecting optical isomer in bedaquiline fumarate | 浙江海正药业股份有限公司 | 2024-06-07 | — | — | CN | disclosed |
| CN-117603137-A | Method for chiral synthesis of (1R, 2S) -bedaquiline | 沈阳红旗制药有限公司 | 2024-02-27 | — | — | CN | disclosed |
| CN-117269345-A | Liquid phase detection method for small molecular organic amine substances | 陕西汉江药业集团股份有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-113527305-A | Pharmaceutically acceptable salts of quinoline TGF-beta 1 inhibitor and preparation method thereof | 南京圣和药物研发有限公司 | 2021-10-22 | — | — | CN | disclosed |
| CN-109422679-A | A kind of shellfish is up to the purifying of quinoline and the preparation method of stable crystal form | 武汉武药科技有限公司 | 2019-03-05 | — | — | CN | disclosed |
| CN-1143675-C | Heteroarylpiperidines, pyrrolidines and piprazines and their use as antipsychotics and analgetics | ���µ�˹ҩ�﹫˾ | 2004-03-31 | — | — | CN | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |
| US-RE37478-E1 | COMPOUNDS WITH HETEROCYCLIC AMINO COMPOUNDS | AVENTIS PHARMACEUTICALS, INC. | 2001-12-18 | — | — | US | disclosed |
| CN-1037266-C | Quinoline derivative fumarates | MITSUI TOATSU CHEMICALS (JP) | 1998-02-04 | — | — | CN | disclosed |
| CN-1083476-A | The fumarate of quinoline | MITSUI TOATSU CHEMICALS (JP) | 1994-03-09 | — | — | CN | disclosed |
| US-5104885-A | 5-(phenylalkoxy)primaquine and 5[(heterocycle)alkoxy] primaquine compounds and their use for treatment of malaria | CALSPAN CORPORATION (US) | 1992-04-14 | — | — | US | disclosed |
| CN-85105798-A | Octahydro- azoles is the preparation method of [4,5-g] quinoline also | — | 1987-01-28 | — | — | CN | disclosed |
| CN-85101547-A | The preparation method and its usage of novel octahydro thiazole [4,5-g] and quinoline compound | — | 1987-01-24 | — | — | CN | disclosed |
| US-4311844-A | Octahydro-2H-pyrrolo[3,4,-g]quinolines | ELI LILLY AND COMPANY (US) | 1982-01-19 | — | — | US | disclosed |