Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CHKA | P35790 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.34 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5874482 | 1.00 | CA2 (0.37) | CA2CA12CA1CA9CHKA | |
| SCHEMBL9596607 | 0.92 | HCAR2 (0.39) | CA2CA12CA1CA9CHKA | |
| SCHEMBL9596598 | 0.92 | HCAR2 (0.39) | CA2CA12CA1CA9CHKA | |
| SCHEMBL28719611 | 0.90 | HCAR2 (0.38) | CA2CA12CA1CA9CHKA | |
| Water SCHEMBL28189169 | 0.90 | HCAR2 (0.38) | CA2CA12CA1CA9CHKA | |
| SCHEMBL29040960 | 0.87 | CA12 (0.30) | CA2CA12CA1CA9 | |
| SCHEMBL29283212 | 0.86 | HCAR2 (0.47) | CA2CA12CA1CA9SIGMAR1 | |
| SCHEMBL27791412 | 0.84 | CA2 (0.35) | CA2CA12CA1CA9CHKA | |
| SCHEMBL27670396 | 0.83 | CA2 (0.34) | CA2CA12CA1CA9CHKA | |
| SCHEMBL27452767 | 0.82 | SIGMAR1 (0.41) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102123995-A | Phenyl-alkyl piperazines with TNF modulating activity | SANOFI AVENTIS | 2011-07-13 | — | — | CN | claimed |
| CN-105085421-B | Bit piperazine fumarate difficult to understand, hydrate, crystal formation and preparation method thereof | 深圳市湘雅生物医药研究院 | 2017-12-26 | — | — | CN | disclosed |
| CN-105085421-B | Bit piperazine fumarate difficult to understand, hydrate, crystal formation and preparation method thereof | 深圳市湘雅生物医药研究院 | 2017-12-26 | — | — | CN | disclosed |
| CN-105085421-B | Bit piperazine fumarate difficult to understand, hydrate, crystal formation and preparation method thereof | 深圳市湘雅生物医药研究院 | 2017-12-26 | — | — | CN | disclosed |
| CN-105085421-A | Oxetazine fumarate, hydrate, crystal form and preparation method thereof | SHENZHEN XIANGYA BIOLOG MEDICINE RES INST | 2015-11-25 | — | — | CN | disclosed |
| CN-102123995-A | Phenyl-alkyl piperazines with TNF modulating activity | SANOFI AVENTIS | 2011-07-13 | — | — | CN | disclosed |
| CN-100398103-C | Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance | NEUROSEARCH AS (DK) | 2008-07-02 | — | — | CN | disclosed |
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| CN-1635877-A | Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance | NEUROSEARCH AS (DK) | 2005-07-06 | — | — | CN | disclosed |
| CN-1131211-C | Heteroaryl diazacycloalkanes as cholinergic ligands at nicotinic acetylcholine receptors | NEUROSEARCH AS (DK) | 2003-12-17 | — | — | CN | disclosed |
| CN-1028756-C | Pyridyl-and pyrimidyl derivatives | PHARMACIA AB (SE) | 1995-06-07 | — | — | CN | disclosed |
| US-5183902-A | Muscle relaxants | A. H. ROBINS COMPANY, INCORPORATED (US) | 1993-02-02 | — | — | US | disclosed |
| US-5068231-A | Ureas and thioureas for relaxing muscles | A. H. ROBINS COMPANY INCORPORATED (US) | 1991-11-26 | — | — | US | disclosed |
| CN-1045583-A | Tetrahydrobenzimidazderivative derivative | YAMANOUCHI PHARMA CO LTD (JP) | 1990-09-26 | — | — | CN | disclosed |
| US-4956359-A | CARBOXAMIDES OR THIOCARBOXAMIDES OF ARYL OXY OR THIO AZETIDINES | A. H. ROBINS COMPANY, INC. (US) | 1990-09-11 | — | — | US | disclosed |
| CN-1041360-A | New pyridyl and pyrimidinyl derivatives | PHARMACIA AB (SE) | 1990-04-18 | — | — | CN | disclosed |
| EP-0361271-A1 | Pyridyl- and pyrimidyl derivatives | Kabi Pharmacia AB (SE) | 1990-04-04 | — | — | EP | disclosed |
| CN-1030415-A | Saturated heterocycle carboxamide derivatives and its preparation method | YAMANOUCHI PHARMA CO LTD (JP) | 1989-01-18 | — | — | CN | disclosed |
| CN-88101588-A | Preparation 1, the method for 4-disubstituted piperazines compounds | — | 1988-11-23 | — | — | CN | disclosed |
| EP-0189612-A1 | New pharmaceutical compositions having a psychotropic activity | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1986-08-06 | — | — | EP | disclosed |