Tetrahydrouridine

Tetrahydrouridine

SCHEMBL587704

O=C1NC(O)CCN1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CDA P32320 13/20 0.66
MAPT P10636 1/20 0.46
SLC28A1 O00337 1/20 0.45
SLC28A2 O43868 1/20 0.45
SLC29A1 Q99808 1/20 0.45
SLC28A3 Q9HAS3 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tetrahydrouridine SCHEMBL127270 1.00 CDA (0.66) CDAMAPTSLC28A1SLC28A2SLC29A1
Tetrahydrouridine SCHEMBL171865 1.00 CDA (0.66) CDAMAPTSLC28A1SLC28A2SLC29A1
Tetrahydrouridine SCHEMBL172272 1.00 CDA (0.66) CDAMAPTSLC28A1SLC28A2SLC29A1
Tetrahydrouridine SCHEMBL11761038 1.00 CDA (0.66) CDAMAPTSLC28A1SLC28A2SLC29A1
Tetrahydrouridine SCHEMBL11759489 1.00 CDA (0.66) CDAMAPTSLC28A1SLC28A2SLC29A1
Tetrahydrouridine SCHEMBL14133787 1.00 CDA (0.66) CDAMAPTSLC28A1SLC28A2SLC29A1
SCHEMBL10069547 0.87 CDA (0.59) CDAMAPT
SCHEMBL12338486 0.87 CDA (0.55) CDAMAPT
SCHEMBL12338454 0.87 CDA (0.59) CDAMAPT
SCHEMBL10069752 0.87 CDA (0.59) CDAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024125595-A1 GEMCITABINE ANTI-CANCER DERIVATIVE, ANTI-CANCER PHARMACEUTICAL USE AND PREPARATION METHOD THEREFOR 深圳艾欣达伟医药科技有限公司 2024-06-20 WO disclosed
US-20210077492-A1 METHODS AND COMPOSITIONS OF TREATING PANCREATIC CANCER THE TRUSTEES OF INDIANA UNIVERSITY 2021-03-18 US disclosed
EP-2416780-B1 COMBINATION OF DECITABINE WITH CYTIDINE DEAMINASE INHIBITOR AND USE THEREOF IN THE TREATMENT OF CANCER OTSUKA PHARMA CO LTD (JP) 2017-03-08 EP disclosed
EP-2416781-B1 COMBINATION OF CYTIDINE-BASED ANTINEOPLASTIC DRUGS WITH CYTIDINE DEAMINASE INHIBITOR AND USE THEREOF IN THE TREATMENT OF CANCER OTSUKA PHARMA CO LTD (JP) 2017-03-08 EP disclosed
EP-2416780-B1 COMBINATION OF DECITABINE WITH CYTIDINE DEAMINASE INHIBITOR AND USE THEREOF IN THE TREATMENT OF CANCER OTSUKA PHARMA CO LTD (JP) 2017-03-08 EP disclosed
EP-2416781-B1 COMBINATION OF CYTIDINE-BASED ANTINEOPLASTIC DRUGS WITH CYTIDINE DEAMINASE INHIBITOR AND USE THEREOF IN THE TREATMENT OF CANCER OTSUKA PHARMA CO LTD (JP) 2017-03-08 EP disclosed
US-9567363-B2 Certain compounds, compositions and methods OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2017-02-14 US disclosed
EP-2417146-B1 (2'-DEOXY-RIBOFURANOSYL)-1,3,4,7-TETRAHYDRO-(1,3)DIAZEPIN-2-ONE DERIVATIVES FOR TREATING CANCER OTSUKA PHARMA CO LTD (JP) 2016-07-13 EP disclosed
US-20150210730-A1 CERTAIN COMPOUNDS, COMPOSITIONS AND METHODS TAIHO PHARMACEUTICAL CO., LTD. (JP) 2015-07-30 US disclosed
US-9040501-B2 Compositions and methods for treating cancer OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2015-05-26 US disclosed
US-20100279977-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER EISAI INC. (US) 2010-11-04 US disclosed
US-20100279977-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER EISAI INC. (US) 2010-11-04 US disclosed
US-20100279977-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER EISAI INC. (US) 2010-11-04 US disclosed
US-20100279967-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER EISAI INC. (US) 2010-11-04 US disclosed
WO-2010118006-A1 (2 ' -DEOXY-RIBOFURANOSYL) -1,3,4, 7-TETRAHYDRO- (1,3) IAZEPIN-2-0NE DERIVATIVES FOR TREATING CANCER EISAI INC. (US) 2010-10-14 WO disclosed
WO-2010118010-A1 COMBINATION OF DECITABINE WITH CYTIDINE DEAMINASE INHIBITOR AND USE THEREOF IN THE TREATMENT OF CANCER EISAI INC. (US) 2010-10-14 WO disclosed
WO-2010118013-A1 COMBINATION OF CYTIDINE-BASED ANTINEOPLASTIC DRUGS WITH CYTIDINE DEAMINASE INHIBITOR AND USE THEREOF IN THE TREATMENT OF CANCER EISAI INC. (US) 2010-10-14 WO disclosed
US-4172889-A ANTIINFLAMMATORY THE UPJOHN COMPANY (US) 1979-10-30 US disclosed
US-4118484-A ANTIINFLAMMATORY AGENT THE UPJOHN COMPANY (US) 1978-10-03 US disclosed
US-4017606-A CYTOSINE ARABINOSIDE AND HYDROGENATED PYRIMIDINE NUCLEOSIDES THE UPJOHN COMPANY (US) 1977-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100279977-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER RNASE1, UNG, HCCS CDA 537/4885MAPT 4204/4885SLC28A1 3363/4885
US-20100279967-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER UNG, DUT, DCTD CDA 49/4885MAPT 4434/4885SLC28A1 1227/4885
US-20150210730-A1 CERTAIN COMPOUNDS, COMPOSITIONS AND METHODS DUT, TYMP, DPYD CDA 134/4885MAPT 1627/4885SLC28A1 1165/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.